Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Platelet activation and aggregation are essential to limit blood loss at sites of vascular injury but may also lead to occlusion of diseased vessels. The platelet cytoskeleton is a critical component for proper hemostatic function. Platelets change their shape after activation and their contractile machinery mediates thrombus stabilization and clot retraction. In vitro studies have shown that platelets, which come into contact with proteins such as fibrinogen, spread and first form filopodia and then lamellipodia, the latter being plate-like protrusions with branched actin filaments. However, the role of platelet lamellipodia in hemostasis and thrombus formation has been unclear until recently. This short review will briefly summarize the recent findings on the contribution of the actin cytoskeleton and lamellipodial structures to platelet function.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1055/a-1325-0993 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Arterial thrombosis is a multifaceted process characterized by platelet aggregation and fibrin deposition, leading to the occlusion of blood vessels. It plays a central role in cardiovascular conditions such as myocardial infarction and ischemic stroke. Gaining insight into the mechanisms underlying arterial thrombosis is essential for developing effective treatments aimed at preventing thrombotic events and reducing associated health burdens.
View Article and Find Full Text PDFImmediate complications and risk factors following radial arterial catheterisation in paediatric patients at a tertiary centre.
Eur J Anaesthesiol
September 2025
From the Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea (J-HL, J-BP, S-HJ, Y-EJ, E-HK, J-TK, H-SK).
Background: Arterial catheterisation is a critical procedure in paediatric patients undergoing surgery; however, it poses certain risks. Complications such as thrombus formation, arterial stenosis and haematoma may occur, yet their true incidence and contributing factors remain incompletely understood.
Objective: To assess the incidence of complications and identify associated risk factors following radial arterial catheterisation in paediatric patients.
Thrombotic complications after aortic arch replacement with frozen elephant trunk stent-graft: A 10-year United Kingdom institutional experience.
JTCVS Open
August 2025
Department of Anaesthesia and Intensive Care Medicine, Royal Papworth Hospital, Cambridge Biomedical Campus, Cambridge, United Kingdom.
Objective: Postoperative intraluminal thrombosis after frozen elephant trunk replacement has been reported to occur with a frequency of 6% to 17% and is associated with poor outcomes. The purpose of this institutional review is to analyze thrombosis rate, predisposing patient and operative factors, and assess different anticoagulation regimens.
Methods: This retrospective cohort study includes 174 patients operated on over 10 years.
Effect of Empagliflozin on the plasma lipidome in patients with type 2 diabetes mellitus: results from the EmDia clinical trial.
Cardiovasc Diabetol
September 2025
Computational Biomedicine, Center for Thrombosis and Hemostasis (CTH), Mainz, Germany.
Background: Sodium-glucose cotransporter 2 (SGLT2) inhibitors, such as Empagliflozin, are antidiabetic drugs that reduce glucose levels and have emerged as a promising therapy for patients with heart failure (HF), although the exact molecular mechanisms underlying their cardioprotective effects remain to be fully elucidated. The EmDia study, a randomized, double-blind trial conducted at the University Medical Center of Mainz, has confirmed the beneficial effects of Empagliflozin in HF patients after both one and twelve weeks of treatment. In this work, we aimed to assess whether changes in lipid profiles driven by Empagliflozin use in HF patients in the EmDia trial could assist in gaining a better understanding of its cardioprotective mechanisms.
View Article and Find Full Text PDF[Glomangiomatosis of uncertain malignant potential: a clinicopathological and genetic analysis].
Zhonghua Bing Li Xue Za Zhi
September 2025
Department of Pathology, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou 450003, China.
To investigate the clinicopathological features, genetic characteristics, and differential diagnosis of glomangiomatosis with uncertain malignant potential. Two cases of glomangiomatosis with uncertain malignant potential were collected at Henan Provincial People's Hospital from 2013 and 2023. Immunohistochemistry and next generation sequencing (DNA-seq) were used to detect the related protein and gene variation.
View Article and Find Full Text PDF