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Aim: The aim of this study is to highlight our experience about the use of open Abdomen's technique as strategy for the management of complicated colon diverticulitis with a delayed anastomosis or colostomy.
Materials And Methods: Thirty patients, with III and IV Hinchey stage, have been undertaken to a surgical procedure with Open Abdomen technique and application of Ab-thera device. A second surgical look was made after 48-72 hours in order to evaluate the possibility to do an anastomosis or colostomy.
Results: No deaths in patients with anastomosis were reported, but one case of leakage at the 8th day and one case of micro pulmonary embolism had been displayed. Elderly patients were discharged between the 15TH /18th day. One patient affected by lymphoma was sent in haematology department for other treatment.
Discussion: Today trend is to treat the diverticular disease with colic and paracolic abscess by a medical therapy and percutaneous drainage under CT scan or ultrasound view. With III and IV of Hinchey scale we perform the resection with anastomosis or colostomy. The open abdomen technique allows the surgeons to make the decision of colostomy or anastomosis in the second surgical look at 48-72 hours after the first treatment with irrigation and aspiration during AB-Thera.
Conclusion: The Open Abdomen technique is a valid therapeutic alternative approach for patients with acute diverticulitis disease in III and IV Hinchey grade. This therapeutic approach gives important advantages in patients with delayed colostomy.
Key Words: Diverticulitis, Damage Control Surgery, Open Abdomen.
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J Clin Pharmacol
September 2025
CSL Behring LLC, King of Prussia, PA, USA.
Garadacimab is a novel, fully human, anti-activated factor XII monoclonal antibody approved for long-term prophylaxis of patients with hereditary angioedema. This open-label, parallel-group, Phase 1, single-center, bridging study in healthy adults (18-55 years of age) characterized the pharmacokinetics and safety of a single 200 mg subcutaneous injection of garadacimab administered via autoinjector/pre-filled pen (AI/PFP) compared with the pre-filled syringe (PFS) used in previous studies. The aim of the study was to bridge the understanding of the PK and safety of garadacimab between PFS and AI/PFP modes of administration.
View Article and Find Full Text PDFJ Surg Case Rep
September 2025
Department of Surgery, Prince Mohammed Bin Abdulaziz Hospital, Riyadh, Saudi Arabia.
Gastric outlet obstruction (GOO) is an uncommon, yet potentially severe, condition arising from multiple causes, including ingesting foreign bodies. The formation of plastic bezoars or trichobezoars due to swallowing indigestible materials remains a rare cause, especially among children exhibiting pica behavior (Vaughan The Rapunzel syndrome: an unusual complication of intestinal bezoar. 1968;:339-43).
View Article and Find Full Text PDFBMJ Open Sport Exerc Med
September 2025
Servizio di Endocrinologia e Diabetologia, Repubblica e Cantone Ticino Ente Ospedaliero Cantonale, Bellinzona, TI, Switzerland.
Background: The use of continuous glucose monitors (CGM) in scuba diving for patients with type 1 diabetes (T1DM) shows potential but faces challenges related to accuracy. Previous research has highlighted the poor accuracy of the Dexcom G7 (DG7) in repetitive diving contexts. This study investigates the impact of calibration on the accuracy of DG7, providing valuable insights for patients and clinicians.
View Article and Find Full Text PDFCureus
August 2025
Department of Diagnostic Radiology and Nuclear Medicine, Rush University Medical Center, Chicago, USA.
Ventriculoperitoneal (VP) shunt placement is a common and effective intervention for managing hydrocephalus. While generally successful, this procedure can be associated with rare but serious complications, including cerebrospinal fluid (CSF) pseudocyst formation. These loculated, epithelial-free fluid collections typically form around the distal catheter in the peritoneal cavity and are more commonly seen in pediatric patients.
View Article and Find Full Text PDFCureus
August 2025
Obstetrics and Gynaecology, Whittington Health National Health Service (NHS) Trust, London, GBR.
Hematometra is an uncommon and delayed complication following the surgical management of miscarriage. When it occurs in the early postoperative period, it is sometimes referred to as "Redo syndrome". We present the case of a 39-year-old woman who developed this rare condition following a suction and evacuation procedure performed for a missed miscarriage.
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