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http://dx.doi.org/10.1093/rheumatology/keab081 | DOI Listing |
Immunity
June 2025
Gulbenkian Institute for Molecular Medicine, Av. Professor Egas Moniz, 1649-028 Lisboa, Portugal. Electronic address:
Evolutionary medicine integrates principles of evolutionary biology to understand and treat human diseases. As a classical example, positive selection of the sickle hemoglobin mutation, which confers a survival advantage against malaria in heterozygous individuals, causes sickle cell disease in homozygotes. In this issue of Immunity, Zilong Zhao et al.
View Article and Find Full Text PDFFront Immunol
June 2025
Department of Thyroid Head and Neck Surgery, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan, China.
Metabolic reprogramming is a process by which cells adapt to the nutrient microenvironment by regulating energy metabolism. Compared with normal cells, tumor cells tend to undergo metabolic reprogramming, which is one of the hallmarks of concurrent genomic instability, and immune evasion in tumor cells. The microbial community, known as "second genome" of human beings, can cause systemic disease by predisposing cells to tumors, and modulating immune responses to cancer.
View Article and Find Full Text PDFeGastroenterology
April 2025
Departamento de Gastroenterología, Pontificia Universidad Católica de Chile, Santiago, Chile.
Background: Severe alcohol-associated hepatitis (sAH) is a life-threatening condition with high mortality, where corticosteroid use is the only treatment that has shown short-term benefits. Pentoxifylline, an anti-tumour necrosis factor-alpha agent, has been proposed for its potential to improve outcomes, especially in patients with acute kidney injury (AKI). We aimed to evaluate the impact of pentoxifylline on mortality in patients with sAH and AKI in a well-characterised global cohort.
View Article and Find Full Text PDFJAMA Dermatol
May 2025
Research and Innovation Institute, Women's College Hospital, Toronto, Ontario, Canada.
Importance: Systemic treatments for psoriatic disease affect the immune system and may increase infection risk. Older adults are at high risk for infection, and the relative safety of systemic treatments for them is unknown.
Objective: To evaluate the association of systemic treatments for psoriatic disease with rates of serious infection among older adults.
World J Gastroenterol
February 2025
Department of Epidemiology and Statistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan Province, China.
In this article, we comment on the work published by Huang , which explores the mechanisms by which (CB) modulates the liver cancer immune microenvironment the Wnt/β-catenin signalling pathway. The study demonstrates that active components in CB effectively inhibit the activation of the Wnt/β-catenin pathway, significantly reducing the polarization of M2 tumor-associated macrophages. Both and experiments have validated the anti-tumour effects of CB, revealing its complex mechanisms of action through the modulation of immune cell functions within the tumour microenvironment.
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