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http://dx.doi.org/10.1111/bjd.19823 | DOI Listing |
Strahlenther Onkol
September 2025
Department of Radiation Oncology, University Hospital of Münster, Münster, Germany.
The growing use of reduced-dose radiotherapy in patients with primary cutaneous lymphoma is a promising development. Nevertheless, the absence of controlled clinical trials to ascertain standardized doses for each specific type constitutes a significant impediment to the advancement of this field. This expert opinion strongly advocates for advancements in radiation oncology practice that address the unique complexities of primary cutaneous lymphoma.
View Article and Find Full Text PDFAustralas J Dermatol
September 2025
Sydney School of Medicine, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.
We report a case of zosteriform PCMZL presenting in a T3-T4 dermatomal distribution not previously described in the literature. Although the varicella zoster virus was not detected in this case, late diagnosis of the acute eruption of zoster or even preceding zoster 'sine herpete' cannot be excluded as antigenic triggers.
View Article and Find Full Text PDFJ Int Med Res
September 2025
Department of Hematology, Guangzhou Eighth People's Hospital, Guangzhou Medical University, China.
ObjectiveAccurate prognostication is crucial for managing human immunodeficiency virus (HIV)-associated cutaneous T-cell lymphoma. In this study, we aimed to develop an improved machine learning-based prognostic model for predicting the 5-year survival rates in HIV-associated cutaneous T-cell lymphoma patients.MethodsWe derived and tested machine learning models using algorithms including Extreme Gradient Boosting (XGBoost), Light Gradient Boosting Machine (LightGBM), and Random Forest.
View Article and Find Full Text PDFCureus
August 2025
Dermatology, Centro Medico Nacional 20 de Noviembre, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Mexico City, MEX.
Primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL-LT), is an uncommon and aggressive subtype of cutaneous B-cell lymphoma, typically affecting elderly women and predominantly involving the lower extremities. Its diagnosis relies on immunohistochemical profiling and clinical presentation. We report a rare case of a 45-year-old male presenting initially with scalp and supraciliary plaques.
View Article and Find Full Text PDFFront Immunol
September 2025
Laboratory of Molecular Oncology, Istituto Dermopatico dell'Immacolata IDI-IRCCS, Rome, Italy.
Background: Sézary syndrome (SS) is an aggressive and leukemic variant of Cutaneous T-cell Lymphoma (CTCL) with an incidence of 1 case per million people per year. It is characterized by a complex and heterogeneous profile of genetic alteration ns that has so far precluded the development of a specific and definitive therapeutic intervention.
Methods: Deep-RNA-sequencing (RNA-seq) data were used to analyze the single nucleotide variants (SNVs) carried by 128 putative CTCL-driver genes, previously identified as mutated in genomic studies, in longitudinal SS samples collected from 17 patients subjected to extracorporeal photopheresis (ECP) with Interferon-α.