Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Androgen receptor splice variant V7 (AR-V7) was recently detected in circulating tumor cells of castration-resistant prostate cancer (PC) patients and its expression correlated with resistance to new-generation androgen signaling inhibitors.
Objectives: We retrospectively analyzed whether AR-V7 expression was detectable on radical prostatectomy (RP) specimens of untreated nonmetastatic PC cases, and whether it could be associated with progression after surgery.
Method: The expression of AR-V7 and AR-FL (full length) was separately evaluated by immunohistochemistry using a streptavidin-biotin-peroxidase system with 2 anti-AR-V7 and anti-AR-FL rabbit monoclonal antibodies.
Results: 56 PC cases, classified by their clinical risk, were analyzed. Positive expression was found in 24/32 cases in the high-risk group, 4/13 in the intermediate-risk group, and only 2/11 in the low-risk group. We found a significant correlation between AR-V7 positivity and both risk classification (p < 0.001) and progression after surgery (p < 0.001).
Conclusions: In our population of untreated nonmetastatic PC, AR-V7 is detectable by immunohistochemistry in more than 50% of cases. At this early stage, AR-V7 positivity is associated with risk classification and it can predict progression after surgery.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1159/000512445 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Cross-cultural adaptation and psychometric validation of the Finnish version of the Expanded Prostate Cancer Index Composite-26 for patients with localised prostate cancer.
Scand J Urol
August 2025
Department of Urology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Objective: The study aimed to culturally adapt the Expanded Prostate Cancer Composite-26 (EPIC-26) questionnaire to Finnish and evaluate its usability in routine clinical practice in Finland.
Material And Methods: We translated the EPIC-26 questionnaire into Finnish, reviewed it, back-translated it into English, and reviewed it again. We evaluated the questionnaire in four high-volume university hospitals in Finland.
Circulating Tumor DNA (ctDNA) is Reliably Detected in Patients with Metastatic Malignant Phyllodes Tumors, a Feasibility Study.
Ann Surg Oncol
July 2025
Duke Cancer Institute, Duke University, Durham, NC, USA.
Background: Malignant phyllodes tumors (MPT) are biologically aggressive breast neoplasms, with high local and distant recurrence rates and a median survival of 12 months when metastatic. With a disease-free interval often less than 2 years, circulating tumor DNA (ctDNA) may allow for earlier identification of patients with MPT at risk for recurrence. Here, we aim to determine the feasibility of detecting ctDNA in (1) patients with known, active metastatic disease and (2) patients with nonmetastatic MPT prior to surgical resection.
View Article and Find Full Text PDFThe Efficacy of Neoantigen-Loaded Dendritic Cell Vaccine Immunotherapy in Non-Metastatic Gastric Cancer.
Med Sci (Basel)
July 2025
First University Surgical Department, Papageorgiou General Hospital, School of Medicine, Aristotle University of Thessaloniki, 56429 Thessaloniki, Greece.
Introduction: Gastric cancer (GC) is the third leading cause of cancer-related deaths worldwide. Even though surgery and chemotherapy are the mainstay of treatment, immunotherapy, and more specifically anti-tumor vaccination, has gained popularity over the past years due to the lower related toxicity and fewer long-term side effects. Dendritic cell (DC) vaccines have been shown to induce tumor specific cytotoxic T-cell (CTL) responses both in vitro and in vivo; however, due to the nature of the disease, resistance to immunotherapy is often developed.
View Article and Find Full Text PDF[Information and screening for sexual disorders of patients with non-metastatic breast cancer: Results of a survey].
Gynecol Obstet Fertil Senol
July 2025
Département de chirurgie gynécologique et oncologique, Institut Universitaire du Cancer de Toulouse-Oncopole, 1, avenue Irène-Joliot-Curie, 31059 Toulouse, France.
Objectives: The diagnosis of breast cancer and the several treatments lead to sexual disorders in 40 to 60% of patients, impacting their quality of life and the one of the couple, even years after cancer. For a long time, the subject was ignored and these disorders untreated. This study aimed to carry out an inventory of information and screening for sexual disorders after breast cancer and to identify potential barriers to their application.
View Article and Find Full Text PDFPrevalence and Prognostic Significance of Preoperative Anemia in Radical Cystectomy Patients: A Multicenter Retrospective Observational Study.
Eur Urol Open Sci
July 2025
Department of Urology, Luzerner Kantonsspital, University of Lucerne, Lucerne, Switzerland.
Background And Objective: Preoperative anemia is common in patients undergoing radical cystectomy for bladder cancer, but its prevalence and impact on outcomes remain poorly characterized across different health care settings. This study aims to assess the prevalence of preoperative anemia, evaluate its current management practices, and determine its association with postoperative and oncological outcomes in patients undergoing radical cystectomy.
Methods: We retrospectively analyzed 4886 patients with nonmetastatic bladder cancer who underwent radical cystectomy across 28 centers in 13 countries.