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http://dx.doi.org/10.1016/j.psym.2020.07.004 | DOI Listing |
World J Clin Cases
September 2025
Department of Radiology, Lifetree Healthcare, Zirakpur 140603, Punjab, India.
Background: Tramadol is a synthetic opioid analgesic commonly employed in postoperative pain control due to its moderate efficacy and comparatively favorable safety profile. Nonetheless, overdose can result in significant adverse effects, notably central nervous system depression. This risk is amplified in individuals with chronic kidney disease (CKD), where reduced renal clearance may potentiate drug accumulation and toxicity.
View Article and Find Full Text PDFSubst Use Addctn J
August 2025
Department of Emergency Medicine, Rutgers New Jersey Medical School, Newark, NJ, USA.
Background: With increasing frequency, providers are encountering patients with opioid overdose who recrudesce after intermittent bolus dosing of naloxone. Some patients require a continuous infusion to maintain ventilation, which necessitates admission to a monitored setting. Buprenorphine could shorten the duration of a continuous naloxone infusion (CNI) or preclude the need altogether because its long-lasting partial agonist effects compete with and blunt the respiratory depressant effects of full agonist opioids.
View Article and Find Full Text PDFAm J Vet Res
July 2025
Section of Anesthesiology and Pain Medicine, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY.
Objective: To evaluate the efficacy of bilateral transversus abdominis plane (TAP) blocks using either liposomal bupivacaine (2.66 mg/kg) expanded with bupivacaine hydrochloride (HCl; 0.5%; 2 mg/kg) or bupivacaine HCl (0.
View Article and Find Full Text PDFAddict Sci Clin Pract
July 2025
British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada.
Background: Most opioid use disorder (OUD) treatment guidelines target community medical settings, and the subsequent recommendations were established to prioritize safety and reduce diversion prior to the fentanyl era. For people with OUD who use unregulated fentanyl, slow induction onto opioid agonist therapy (OAT) with gradual dose titration is often ineffective or insufficient for reducing withdrawal symptoms and cravings, thereby hampering engagement and retention in treatment. Given the severe risks associated with continued use of the increasingly toxic unregulated drug supply, new and innovative approaches to the management of OUD are urgently needed.
View Article and Find Full Text PDFJ Am Assoc Lab Anim Sci
July 2025
1Department of Comparative Medicine, University of Washington, Seattle, Washington.
Alfaxalone has been studied for anesthetic induction of rabbits with rapid onset and a short duration of action; however, it has been minimally evaluated as an option for anesthetic maintenance. This study compared alfaxalone-based total intravenous anesthesia maintenance protocols against inhaled isoflurane, the current standard for anesthetic maintenance in rabbits. Twenty-four male New Zealand White rabbits were assigned to 1 of 3 treatment groups: isoflurane alone, alfaxalone with buprenorphine, or alfaxalone with midazolam.
View Article and Find Full Text PDF