Illuminating Non-genetic Cellular Heterogeneity with Imaging-Based Spatial Proteomics.

Trends Cancer

Science for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH - Royal Institute of Technology, Stockholm, 17121, Sweden. Electronic address:

Published: April 2021


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Article Abstract

Cellular heterogeneity is an important biological phenomenon observed across space and time in human tissues. Imaging-based spatial proteomic technologies can provide fruitful new readouts of phenotypic states for individual cells at subcellular resolution, which may help unravel the roles of non-genetic cellular heterogeneity in tumorigenesis and drug resistance.

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http://dx.doi.org/10.1016/j.trecan.2020.12.006DOI Listing

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