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Cellular heterogeneity is an important biological phenomenon observed across space and time in human tissues. Imaging-based spatial proteomic technologies can provide fruitful new readouts of phenotypic states for individual cells at subcellular resolution, which may help unravel the roles of non-genetic cellular heterogeneity in tumorigenesis and drug resistance.
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http://dx.doi.org/10.1016/j.trecan.2020.12.006 | DOI Listing |
Cancer Immunol Res
September 2025
Alligator Bioscience (Sweden), Lund, Sweden.
Despite recent progress within the field of immuno-oncology, immune suppression in the tumor microenvironment, defective antigen presentation, and low levels of tumor-specific T cells are key limitations of current cancer immunotherapies. CD40-targeting immunotherapies hold promises for addressing these limitations across solid tumors. Here, we describe ATOR-4066, a bispecific antibody that targets CD40 and CEACAM5 developed for immunotherapy of cancer using the Neo-X-Prime platform.
View Article and Find Full Text PDFChaos
September 2025
Instituto de Física, Universidade Federal de Alagoas, Maceió, Alagoas 57072-970, Brazil.
Neuronal heterogeneity, characterized by a multitude of spiking neuronal patterns, is a widespread phenomenon throughout the nervous system. In particular, the brain exhibits strong variability among inhibitory neurons. Despite the huge neuronal heterogeneity across brain regions, which in principle could decrease synchronization due to differences in intrinsic neuronal properties, cortical areas coherently oscillate during various cognitive tasks.
View Article and Find Full Text PDFmBio
September 2025
Department of Microbiology, Oregon State University, Corvallis, Oregon, USA.
Quorum sensing (QS) is a widespread signaling mechanism in bacteria that coordinates collective behaviors according to population density. A foundational assumption in this field is that QS functions as a gene expression switch that synchronizes responses at the population level. While some studies indeed report homogeneous on/off transitions, others report heterogeneity at the cellular level, challenging the canonical view.
View Article and Find Full Text PDFAm J Med Genet B Neuropsychiatr Genet
September 2025
The Central Lab, the Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, People's Republic of China.
Autism spectrum disorder (ASD) is a neurodevelopmental condition that is increasingly linked to immune dysfunction and neuroinflammation. Regulatory T cells (Tregs), which are crucial in maintaining immune homeostasis, have been implicated in the pathogenesis of ASD. However, their role in neuroimmune interactions and behavioral outcomes remains poorly understood.
View Article and Find Full Text PDFCytopathology
September 2025
Department of Cardiothoracic and Vascular Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.
Mediastinal masses often present acutely as medical emergencies, necessitating prompt and accurate diagnosis. Imaging-guided fine needle aspiration cytology (FNAC) plays a pivotal role in rapidly identifying rare mediastinal tumours and differentiating them from other potential aetiologies, enabling timely intervention. Primary mediastinal germ cell tumours (PMGCTs) constitute approximately 15% of adult mediastinal neoplasms.
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