Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background/aim: Intraarterial Technetium-99m-Macroaggregated Albumin (Tc-MAA) administration is an established method to predict particle distribution prior to radioembolization. This study aimed to analyse the impact of intraarterial administration of Tc-MAA on changes in liver-specific laboratory parameters and to assess whether such changes are associated with post-radioembolization hepatotoxicity.
Patients And Methods: A total of 202 patients treated with radioembolization received prior mapping angiography with Tc-MAA administration. All patients underwent clinical and laboratory examinations, including liver-specific parameters at certain times before and after mapping angiography/Tc-MAA administration, as well as before radioembolization and during follow-up.
Results: Bilirubin increased temporarily after Tc-MAA administration (p<0.001), but was not clinically relevant, and returned close to the initial value before radioembolization. These changes showed no association with subsequent postradioembolic hepatotoxicity or shortened overall survival.
Conclusion: Tc-MAA administration results in a significant, however, not clinically relevant transient increase in bilirubin levels, which does not provide a predictive value for subsequent radioembolization outcome or postradioembolic hepatotoxicity.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.21873/anticanres.14793 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
SPECT/CT Dosimetry of Bronchial Artery Tc Macroaggregated Albumin Injection in Pulmonary Malignancies: Feasibility Evaluation of Bronchial Artery Y Radioembolization.
Radiology
February 2025
Department of Radiation Oncology, Massachusetts General Hospital, Boston, Mass.
Background External beam radiation therapy for primary and secondary pulmonary malignancies has limited utility for treating ultracentral tumors (ie, adjacent to the proximal bronchial tree or heart) or multiple metastases due to either radiation to central organs at risk (OARs) or extensive lung tissue exposure. Bronchial artery yttrium 90 (Y) radioembolization may be a therapeutic option for these patients. Purpose To evaluate the feasibility of bronchial artery Y radioembolization using technetium 99m (Tc) macroaggregated albumin (MAA) injection as a surrogate for Y microspheres and to use SPECT/CT dosimetry to assess Tc-MAA distribution and calculated anticipated Y doses to tumors and OARs.
View Article and Find Full Text PDFNon-palpable Pulmonary Nodules and Uniportal-VATS: Radio-guided Localization (ROLL) Experience of a Lung Multidisciplinary Team.
Anticancer Res
August 2024
Medical Oncology Unit, Casa di Cura Torina, Palermo, Italy;
Background/aim: Surgical resection with a minimally invasive approach is the standard for diagnosing and treating solitary pulmonary nodules. A computed tomography (CT)-guided technetium-macroaggregated albumin (Tc-MAA) injection-based procedure has been employed for small and non-palpable lung nodule radio-guided preoperative localization (ROLL). This procedure is usually followed by video-assisted thoracoscopic surgery (VATS).
View Article and Find Full Text PDFInfluence of Early Versus Delayed Hepatic Artery Perfusion Scan on Y Selective Internal Radiation Therapy Planning.
Cancer Biother Radiopharm
June 2024
Department of Nuclear Medicine, Istanbul Faculty of Medicine, Istanbul University, Fatih/İstanbul, Turkey.
Article Synopsis
- - The study assessed how the timing of HAPS after injecting Tc-MAA affects lung shunt fraction (LSF) and perfused volume (PV) in patients receiving selective internal radiation therapy (SIRT) for liver cancer.
- - Researchers analyzed 51 HAPS sessions involving 40 patients, comparing LSF values and PV calculations from scans taken one hour and four hours post-injection.
- - They found LSF values increased significantly from the first hour to the fourth hour, but PV calculations remained consistent; delaying HAPS could lead to overestimations of LSF, potentially impacting treatment decisions.
[Impact of Residual Radioactivity Rate of Tc-macro Aggregated Albumin (MAA) in Syringes and Administration Routes with a Focus on Pediatric Nuclear Medicine Examinations].
Nihon Hoshasen Gijutsu Gakkai Zasshi
August 2023
Department of Nuclear Medicine, Kawasaki Medical School.
Purpose: The purpose of this study was to evaluate the residual radioactivity in the syringe and route of administration of a low fluid volume Tc-macro aggregated albumin (MAA) intended for pediatric nuclear medicine examinations.
Method: We evaluated the residual characteristics, as the effect of elapsed time from drawing up of radiopharmaceuticals to plastic syringe to administration, and the effect of volume of TcO solution to be labeled, the effect of rinsed times of plastic syringe, effect of dose of calculated by consensus guidelines for pediatric nuclear medicine and residual location in injection sets with Tc-MAA. Residual radioactivity was measured using planar images obtained by the gamma camera.
Biomarkers to Predict Lethal Radiation Injury to the Rat Lung.
Int J Mol Sci
March 2023
Division of Biostatistics, Institute for Health and Equity, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Currently, there are no biomarkers to predict lethal lung injury by radiation. Since it is not ethical to irradiate humans, animal models must be used to identify biomarkers. Injury to the female WAG/RijCmcr rat has been well-characterized after exposure to eight doses of whole thorax irradiation: 0-, 5-, 10-, 11-, 12-, 13-, 14- and 15-Gy.
View Article and Find Full Text PDF