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We present a series of synthetic polymer hydrogels which break the traditional correlation between pore size and mechanical properties. The hydrogels are prepared from a dendronised polymer architecture based on a methacrylate copolymer to which poly(amido amine) dendrons are attached. Our approach will be useful in tailoring hydrogels for tissue engineering, controlled drug release, and flexible electronics.
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http://dx.doi.org/10.1039/d0cc07115c | DOI Listing |
Chem Commun (Camb)
January 2021
School of Molecular Sciences, The University of Western Australia, 35 Stirling Hwy, Crawley, WA 6009, Australia.
We present a series of synthetic polymer hydrogels which break the traditional correlation between pore size and mechanical properties. The hydrogels are prepared from a dendronised polymer architecture based on a methacrylate copolymer to which poly(amido amine) dendrons are attached. Our approach will be useful in tailoring hydrogels for tissue engineering, controlled drug release, and flexible electronics.
View Article and Find Full Text PDFRSC Adv
June 2019
School of Molecular Sciences, The University of Western Australia 35 Stirling Hwy Crawley WA 6009 Australia
Advances in the field of genome engineering demand the development of efficient non-viral transfection agents capable of delivering multiple distinct nucleic acids efficiently to cells (co-transfection). However, current delivery methods result in lower co-transfection efficiency than single plasmid transfections, and the efficiency decreases further with increasing numbers of plasmids. The development of a high-throughput methodology is required for the validation of co-transfection platforms to facilitate independent tracking of not only the multiple DNA plasmids during transfection but also the localisation of transfection agents.
View Article and Find Full Text PDFChemistry
December 2012
Departamento de Química Inorgánica, Facultad de Ciencias, Instituto de Síntesis Química y Catálisis Homogénea, Universidad de Zaragoza, Spain.
Org Biomol Chem
June 2008
Laboratorium für Organische Chemie, ETH-Zürich, 8093 Zürich, Switzerland.
A series of block copolymers containing a dendronised cationic block for efficient DNA binding and a poly(ethylene glycol) block for encapsulation of the complex were synthesised in a modular fashion using a combination of click chemistry and ring-opening metathesis polymerisation. DNA binding experiments, investigated using gel electrophoresis, dynamic light scattering and transmission electron microscopy, showed that all polymers prepared in this study strongly complex DNA and self-assemble into polyion complex micelles with apparent hydrodynamic radii ranging from 20-120 nm at physiological pH (7.4).
View Article and Find Full Text PDFChem Commun (Camb)
March 2008
Institut de Physique et Chimie des Matériaux de Strasbourg , UMR 7504 CNRS-ULP, Strasbourg Cedex 2, France.
Surface modification of a multiallylic dendronised polymer was performed using hydrosilylation, hydroboration or radical addition of thiols to cover the polymer with various functional moieties; surface congestion is expected to occur when bulky groups are grafted.
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