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The principal objective of this article is to assess the possible association between the number of COVID-19 infected cases and the concentrations of fine particulate matter (PM) and ozone (O), atmospheric pollutants related to people's mobility in urban areas, taking also into account the effect of meteorological conditions. We fit a generalized linear mixed model which includes spatial and temporal terms in order to detect the effect of the meteorological elements and COVID-19 infected cases on the pollutant concentrations. We consider nine counties of the state of New York which registered the highest number of COVID-19 infected cases. We implemented a Bayesian method using integrated nested Laplace approximation (INLA) with a stochastic partial differential equation (SPDE). The results emphasize that all the components used in designing the model contribute to improving the predicted values and can be included in designing similar real-world data (RWD) models. We found only a weak association between PM and ozone concentrations with COVID-19 infected cases. Records of COVID-19 infected cases and other covariates data from March to May 2020 were collected from electronic health records (EHRs) and standard RWD sources.
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http://dx.doi.org/10.3390/ijerph17239055 | DOI Listing |
Ann Geriatr Med Res
September 2025
Academia Latinoamericana de Medicina del Adulto Mayor - ALMA.
Background: Respiratory infections significantly impact older adults in Latin America, highlighting the need for regionally adapted consensus-based vaccination recommendations to guide preventive strategies. This study aimed to develop a consensus among Latin American experts on vaccination against respiratory diseases in older adults in the region, including influenza, Streptococcus pneumoniae pneumonia, COVID-19, respiratory syncytial virus (RSV), and pertussis.
Methods: A two-round Delphi methodology was employed, involving 35 specialists from various medical fields.
Nurs Open
September 2025
Department of Nursing, Central Taiwan University of Science and Technology, Taichung City, Taiwan.
Aim: To explore nursing students' satisfaction levels of each specific item and perceptions under the unprecedented abrupt online clinical practicum during the COVID-19 pandemic.
Design: A mixed-method design comprises a questionnaire and qualitative content analysis.
Methods: The study used purposive sampling using data from nursing students in grade 3 of a 4-year bachelor RN programme at a technological university in the north of Taiwan, compiled from May 2021 to June 2021 using an online questionnaire.
Infect Dis Ther
September 2025
School of Biomedical Sciences, The Chinese University of Hong Kong (CUHK), Hong Kong SAR, China.
Introduction: The high mortality of Coronavirus Disease 2019 (COVID-19) highlights the need for safe and effective antiviral treatment. Small molecular antivirals (remdesivir, molnupiravir, nirmatrelvir/ritonavir) and immunomodulators (baricitinib, tocilizumab) have been developed or repurposed to suppress viral replication and ameliorate cytokine storms, respectively. Despite U.
View Article and Find Full Text PDFAAPS PharmSciTech
September 2025
Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt.
The chimpanzee adenovirus-vectored vaccine developed by the University of Oxford (ChAdOx1 nCoV-19) showed good stability when stored in refrigerator. However, the vaccine manufacturer prefers its transportation in frozen condition. Data regarding the stability of the vaccine after exposure to repeated freezing processes have not been explored yet.
View Article and Find Full Text PDFMol Syst Biol
September 2025
Centre for Individualised Infection Medicine (CiiM), a joint venture between the Helmholtz Centre for Infection Research (HZI) and Hannover Medical School (MHH), Hannover, Germany.
The complex interplay between circulating metabolites and immune responses, which is pivotal to disease pathophysiology, remains poorly understood and understudied in systematic research. Here, we performed a comprehensive analysis of the immune response and circulating metabolome in two Western European cohorts (534 and 324 healthy individuals) and one from sub-Saharan Africa (323 healthy donors). At the metabolic level, our analysis revealed sex-specific differences in the correlation between phosphatidylcholine and cytokine responses following ex vivo stimulation.
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