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Article Abstract
Cell division is often regulated by extracellular signaling networks to ensure correct patterning during development. In , the SHORT-ROOT (SHR)/SCARECROW (SCR) transcription factor dimer activates ; () to drive formative divisions during root ground tissue development. Here, we show plasma-membrane-localized BARELY ANY MERISTEM1/2 (BAM1/2) family receptor kinases are required for -dependent formative divisions and expression, but not -dependent ground tissue specification. Root-enriched CLE ligands bind the BAM1 extracellular domain and are necessary and sufficient to activate -mediated divisions and expression. Correspondingly, BAM-CLE signaling contributes to the restriction of formative divisions to the distal root region. Additionally, genetic analysis reveals that BAM-CLE and SHR converge to regulate additional cell divisions outside of the ground tissues. Our work identifies an extracellular signaling pathway regulating formative root divisions and provides a framework to explore this pathway in patterning and evolution.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768756 | PMC |
| http://dx.doi.org/10.1073/pnas.2018565117 | DOI Listing |
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