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http://dx.doi.org/10.1055/s-0040-1718416 | DOI Listing |
Clin Pharmacol Ther
August 2025
Université Paris Cité and Université Sorbonne Paris Nord, Inserm, IAME, Paris, France.
Levofloxacin is a valuable antibiotic in the treatment of bone and joint infections. Due to the known risk of treatment failure and bacterial resistance, the development of tools facilitating pharmacokinetic/pharmacodynamic parameter monitoring to inform precision dosing is needed. Therefore, we assessed the use of Bayesian estimation to predict AUC and C of levofloxacin under various sampling scenarios realistic in clinical routine.
View Article and Find Full Text PDFPharmaceutics
July 2025
Department of Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, 20900 Monza, Italy.
: Asparaginase (ASPase) plays an important role in the therapy of acute lymphoblastic leukemia (ALL). Serum ASPase activity (SAA) can be modified and even abolished by host immune responses; therefore, current treatment guidelines recommend to monitor SAA during treatment administration. The SAA monitoring schedule needs to be carefully planned to reduce the number of samples without hampering the possibility of measuring pharmacokinetics (PK) parameters in individual patients.
View Article and Find Full Text PDFDrugs Aging
July 2025
Department of Internal Medicine, Haraldsplass Deaconal Hospital, Bergen, Norway.
Background And Objective: Apixaban is the most prescribed direct-acting oral anticoagulant drug. According to its product information, clearance is only partially renal. However, little is known about the impact of renal function on apixaban pharmacokinetics in real-world settings.
View Article and Find Full Text PDFJ Xenobiot
July 2025
Laboratory of Clinical Pharmacology and Pharmacogenetics, Department of Medical Sciences, University of Turin, Amedeo di Savoia Hospital, 10149 Turin, Italy.
Background: Remdesivir (RDV) is a broad-spectrum antiviral prodrug, which is rapidly metabolized in vivo within cells to the pharmacologically active triphosphate metabolite, GS-443902. On the other hand, the dephosphorylated metabolite GS-441524 is the main form detected in plasma. RDV acts against RNA viruses, and it was the first antiviral drug to receive EMA and FDA approval for treating COVID-19.
View Article and Find Full Text PDFAAPS J
June 2025
Synthetic Molecule Design and Development, Eli Lilly and Company, Indianapolis, IN, 46285, United States of America.
In vitro dissolution testing is commonly performed to ensure that oral solid dosage medicines are of high quality and will achieve their targeted in vivo performance. However, this testing is time and material consuming. Therefore, pharmaceutical companies have been developing predictive dissolution models (PDMs) for drug product release based on fast at- and/or on-line measurements, including real-time release testing of dissolution (RTRT-D).
View Article and Find Full Text PDF