The effect of silver diamine fluoride in preventing in vitro primary coronal caries under pH-cycling conditions.

Objectives: This study investigated the ability of SDF, and its individual components, silver (Ag) and fluoride (F) ions, in preventing enamel demineralization under pH-cycling conditions in the presence or absence of twice-daily fluoride application.

Design: Polished human enamel specimens were assigned to five treatment groups (n = 36 per group): SDF (38 %); SDF followed by application of a saturated solution of potassium iodide (SDF + KI); silver nitrate (AgNO; silver control, 253,900 ppm Ag); potassium fluoride (KF; fluoride control, 44,800 ppm F); deionized water. Treatments were applied once. Specimens in each treatment group were divided into two subgroups (n = 18). During the subsequent 7-day pH-cycling phase, specimens were treated twice daily with either 275 ppm fluoride as sodium fluoride or deionized water, immediately before and after a 3-h cariogenic challenge with exposure to artificial saliva at all other times. Changes in color, Vickers surface microhardness (SMH), transverse microradiography (TMR) was calculated. Data were analyzed using two-way ANOVA.

Results: In both models, SDF, SDF + KI and KF were superior in inhibiting demineralization compared to AgNO and deionized water (p < 0.0001). There was no statistically significant difference between SDF, SDF + KI and KF with twice daily fluoride treatments (p > 0.8). However, KF was more effective in preventing demineralization than SDF and SDF + KI in the absence of fluoride treatments (p = 0.0002). KI did not affect the ability of SDF to prevent demineralization (p > 0.4).

Conclusion: SDF and SDF + KI appears to be an effective option in preventing primary coronal caries.