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The prevalence of takotsubo cardiomyopathy (TCM) has been on the rise, but co-occurrence with hypertrophic cardiomyopathy (HOCM) remains rare. Although presenting patient demographics were similar to those in TCM, the potential for hemodynamic compromise was significantly compounded by the presence of underlying HOCM. Management was similar to standalone TCM, although use of inotropic agents and mechanical support appears to be more prevalent. Despite the increased potential for complications and the paucity of data regarding management, outcomes appear to be mostly favorable in both the hospitalization period and at follow-up. Interestingly, despite a new diagnosis of HOCM in about half the cases described, which signifies no significant left ventricular outflow tract (LVOT) gradient prior to TCM, half of those patients had a persistently elevated LVOT gradient after resolution of TCM. This poses a question of whether or not TCM can predispose to LVOT obstruction in HOCM patients even after its resolution.
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http://dx.doi.org/10.1016/j.hrtlng.2020.10.006 | DOI Listing |
Curr Cardiol Rep
September 2025
Department of Cardiovascular Medicine, Mayo Clinic, Phoenix, AZ, USA.
Purpose Of Review: VO₂ max is a fundamental marker of cardiorespiratory fitness with substantial prognostic and diagnostic value within the field of cardiology. This review analyzes current and emerging evidence regarding its clinical uses, highlights key evidence gaps, and explores emerging developments poised to broaden its clinical application.
Recent Findings: Evidence supports VO2 max as a powerful independent predictor for heart failure, coronary artery disease, hypertrophic cardiomyopathy, and cardiac amyloidosis, supporting it use in identifying high-risk patients for advanced interventions.
Europace
September 2025
Department of Cardiovascular Medicine, Mayo Clinic Rochester, Rochester, MN.
JACC Case Rep
September 2025
Hypertrophic Cardiomyopathy Program, NYU Langone Health, New York, New York, USA. Electronic address:
Background: We present the case of a 74-year-old woman diagnosed with obstructive hypertrophic cardiomyopathy.
Case Summary: Amyloidosis was initially considered because she was genotype positive in the transthyretin gene. However, because of 2 negative 99m technetium pyrophosphate radionuclide scans, this diagnosis was considered unlikely, and endomyocardial biopsy was deferred.
JACC Case Rep
September 2025
Aurora Cardiovascular and Thoracic Services, Aurora Sinai/Aurora St Luke's Medical Centers, Milwaukee, Wisconsin, USA; Division of Cardiovascular Medicine, University of Wisconsin School of Medicine and Public Health, Milwaukee Clinical Campus, Milwaukee, Wisconsin, USA.
Images: We present multimodality imaging of ventricular septal calcification.
Case Summary: A 38-year-old man with asymptomatic gene-positive hypertrophic cardiomyopathy was found to have extensive dystrophic calcification of the ventricular septum. We hypothesized that the extensive ventricular septal calcification would represent an area of severe myocardial fibrosis, resulting in calcification secondary to postsurgical (septal myectomy) changes.
Poult Sci
August 2025
Centre for Genetic Improvement of Livestock, Department of Animal Biosciences, University of Guelph, Guelph, ON, Canada; Centre for Nutrition Modelling, Department of Animal Biosciences, University of Guelph, Guelph, ON, Canada; Department of Animal and Veterinary Sciences, Aarhus University, Bliche
Late-stage mortality is a significant challenge for the poultry industry, leading to substantial economic losses, concerns about animal welfare, and operational sustainability. Heart-related conditions, including ascites syndrome, pulmonary hypertension syndrome, hypertrophic cardiomyopathy, and sudden death syndrome, contribute significantly to this issue. The increasing prevalence of these conditions is potentially linked to intense selection pressure aimed at maximizing meat yield, particularly breast meat.
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