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Article Abstract
Introduction: Equol, a metabolite of a soy isoflavone transformed by the gut microbiome, is anti-oxidant and anti-amyloidogenic. We assessed the associations of equol with white matter lesion normalized to total brain volume (WML%) and amyloid beta (Aβ) deposition.
Methods: From 2016 to 2018, 91 cognitively normal elderly Japanese aged 75 to 89 underwent brain magnetic resonance imaging and positron emission tomography using C-Pittsburgh compound-B. Serum equol was measured using stored samples from 2008 to 2012. Equol producers were defined as individuals with serum levels >0. Producers were further divided into high (> the median) and low (≤ the median) producers.
Results: The median (interquartile range) WML% was 1.10 (0.59 to 1.61); 24.2% were Aβ positive, and 51% were equol producers. Equol-producing status (non-producers, low and high) was significantly inversely associated with WML%: 1.19, 0.89, and 0.58, respectively (trend < .01). Equol-producing status was not associated with Aβ status.
Discussion: A randomized-controlled trial of equol targeting WML volume is warranted.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7580022 | PMC |
| http://dx.doi.org/10.1002/trc2.12089 | DOI Listing |
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Article Synopsis
- Equol is a metabolite derived from isoflavones produced by the gut microbiome in some individuals, known as equol-producers (EP), and may help protect against artery hardening (atherogenic factors).
- In a study of 979 Japanese men aged 40-79, those identified as EP showed significantly lower odds of aortic calcification compared to non-EP, suggesting equol's potential protective effect independent of cardiovascular disease (CVD) risk factors.
- Interestingly, while equol levels correlated with reduced aortic calcification, concentrations of isoflavones did not show a significant link to this condition, highlighting equol's unique role in vascular health.