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To manage agricultural landscapes more sustainably, we must understand and quantify the synergies and trade-offs between environmental impact, production, and other ecosystem services. Models play an important role in this type of analysis as generally it is infeasible to test multiple scenarios by experiment. These models can be linked with algorithms that optimise for multiple objectives by searching a space of allowable management interventions (the control variables). Optimisation of landscapes for multiple objectives can be computationally challenging, however, particularly if the scale of management is typically smaller (e.g. field scale) than the scale at which the objective is quantified (landscape scale) resulting in a large number of control variables whose impacts do not necessarily scale linearly. In this paper, we explore some practical solutions to this problem through a case study. In our case study, we link a relatively detailed, agricultural landscape model with a multiple-objective optimisation algorithm to determine solutions that both maximise profitability and minimise greenhouse gas emissions in response to management. The optimisation algorithm combines a non-dominated sorting routine with differential evolution, whereby a 'population' of 100 solutions evolves over time to a Pareto optimal front. We show the advantages of using a hierarchical approach to the optimisation, whereby it is applied to finer-scale units first (i.e. fields), and then the solutions from each optimisation are combined in a second step to produce landscape-scale outcomes. We show that if there is no interaction between units, then the solution derived using such an approach will be the same as the one obtained if the landscape is optimised in one step. However, if there is spatial interaction, or if there are constraints on the allowable sets of solutions, then outcomes can be quite different. In these cases, other approaches to increase the efficiency of the optimisation may be more appropriate-such as initialising the control variables for half of the population of solutions with values expected to be near optimal. Our analysis shows the importance of aligning a policy or management recommendation with the appropriate scale.
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http://dx.doi.org/10.1007/s10661-020-08699-z | DOI Listing |
Driven by eutrophication and global warming, the occurrence and frequency of harmful cyanobacteria blooms (CyanoHABs) are increasing worldwide, posing a serious threat to human health and biodiversity. Early warning enables precautional control measures of CyanoHABs within water bodies and in water works, and it becomes operational with high frequency in situ data (HFISD) of water quality and forecasting models by machine learning (ML). However, the acceptance of early warning systems by end-users relies significantly on the interpretability and generalizability of underlying models, and their operability.
View Article and Find Full Text PDFPLoS One
September 2025
Department of Urology, Kanazawa Medical University, Kahoku, Ishikawa, Japan.
Calcium oxalate (CaOx) stones are prevalent in urinary tract stone disease. While their formation can be induced in rats by administering ethylene glycol and vitamin D, the initial nucleation and formation processes are unclear. Here, we aimed to determine where CaOx crystals initially form, examine the associated histological and morphological changes, and clarify the genes whose expression varies at those sites and their function.
View Article and Find Full Text PDFJ Exp Anal Behav
September 2025
Laboratorio de Análisis de la Conducta, Universidad Nacional Autónoma de México. Facultad de Estudios Superiores Iztacala.
Rules can control the listener's behavior, yet few studies have examined variables that quantitatively determine the extent of this control relative to other rules and contingencies. To explore these variables, we employed a novel procedure that required a choice between rules. Participants clicked two buttons on a computer screen to earn points exchangeable for money.
View Article and Find Full Text PDFPLoS One
September 2025
Department of Cardiology, Fuzhou University Affiliated Provincial Hospital, Fujian Provincial Hospital, Fuzhou, Fujian, China.
Introduction: Kidney stone disease is associated with numerous cardiovascular risk factors. However, the findings across studies are non-uniformly consistent, and the control of confounding variables remains suboptimal. This study aimed to investigate the association between kidney stone and cardiovascular disease.
View Article and Find Full Text PDFInt J STD AIDS
September 2025
Centre for Communicable Diseases Control and Research, Federal Medical Centre, Asaba, Nigeria.
BackgroundMother-to-Child Transmission (MTCT) of HIV continues to be a critical public health issue, particularly in high-prevalence regions. This study examines the rates of MTCT in relation to antenatal booking, parity, antiretroviral (ARV) use, delivery mode, CD4 counts, and infant feeding practices.MethodsA retrospective cross-sectional study was conducted at the Federal Medical Centre, Asaba, Nigeria, involving pregnant women living with HIV attending the Prevention of Mother-to-Child Transmission (PMTCT) program.
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