A comparison of the corneal biomechanics in pseudoexfoliation glaucoma, primary open-angle glaucoma and healthy controls using Corvis ST.

Purpose: To compare the corneal biomechanical parameters between pseudoexfoliation glaucoma (PXG), primary open-angle glaucoma (POAG) and healthy controls using Corvis ST.

Methods: A prospective, cross-sectional study was conducted which included 132 treatment-naïve eyes which underwent Corvis ST. The study cohort comprised of 44 eyes with PXG, 42 eyes with POAG and 46 healthy controls. Corneal biomechanical parameters, which included corneal velocities, length of corneal applanated surface, deformation amplitude (DA), peak distance and radius of curvature, were compared between the groups using analysis of variance models.

Results: The 3 groups were demographically similar. The mean IOP was 15.7 ±3 mmHg in the control group, 21.3 ±5 mmHg in the POAG group and 25.8 ±7 mmHg in the PXG group (p<0.0001). Corneal pachymetry was similar across the 3 groups. Mean DA was significantly lower (p<0.0001) in the PXG group (0.86 ±0.18 mm) compared to the POAG group (0.97 ±0.14mm) and the control group (1.10 ±0.15mm). Corneal velocities were also found to be statistically significantly different between the groups. However, after adjusting for IOP, there was no difference in any of the biomechanical parameters between the 3 groups.

Conclusion: Corneal biomechanical parameters measured on Corvis ST are not different between eyes with PXG, POAG and healthy controls after adjusting for IOP.