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Article Abstract
The incidence and mortality rates of colorectal cancer (CRC) have been high in recent years. Prevention and early detection are crucial for decreasing the death rate. Therefore, this study aims to characterize the alteration patterns of mothers against decapentaplegic homolog 3 () in patients with CRC and its applications in early detection by using a genome-wide methylation array to identify an aberrant hypomethylation site in the intron position of the gene. Quantitative methylation-specific polymerase chain reaction showed that hypomethylated occurred in 91.4% (501/548) of Taiwanese CRC tissues and 66.6% of benign tubular adenoma polyps. In addition, hypomethylation was observed in 94.7% of patients with CRC from The Cancer Genome Atlas dataset. A decrease in circulating cell-free methylation was detected in 70% of CRC patients but in only 20% of healthy individuals. mRNA expression was low in 42.9% of Taiwanese CRC tumor tissues but high in 29.4% of tumors compared with paired adjacent normal tissues. Hypomethylated was found in cancers of the digestive system, such as liver cancer, gastric cancer, and colorectal cancer, but not in breast cancer, endometrial cancer, and lung cancer. In conclusion, hypomethylation is a potential diagnostic marker for CRC in Western and Asian populations.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582763 | PMC |
| http://dx.doi.org/10.3390/ijms21197395 | DOI Listing |
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