Antimicrobial susceptibility of Staphylococcus species isolated from prosthetic joints with a focus on fluoroquinolone-resistance mechanisms.

Diagn Microbiol Infect Dis

Department of Infectious Diseases, Chonnam National University Hospital, Gwangju, Republic of Korea; Department of Infectious Diseases, Chonnam National University Medical School, Gwangju, Republic of Korea. Electronic address:

Published: January 2021


Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

We investigated susceptibility to antimicrobials of 89 staphylococcal species from PJIs and analyzed fluoroquinolone (FQ)-resistance mechanisms. Staphylococcal isolates showed high resistance to oral antimicrobials, with the exception of TMP-STX and linezolid. The main mechanism of resistance to FQ was mutations in quinolone-resistance-determining-regions. Fifteen percent of Staphylococcus aureus overexpressed efflux-pump genes.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.diagmicrobio.2020.115173DOI Listing

Publication Analysis

Top Keywords

antimicrobial susceptibility
4
susceptibility staphylococcus
4
staphylococcus species
4
species isolated
4
isolated prosthetic
4
prosthetic joints
4
joints focus
4
focus fluoroquinolone-resistance
4
fluoroquinolone-resistance mechanisms
4
mechanisms investigated
4

Similar Publications

Fluoroquinolone resistance in , particularly uropathogenic (UPEC), is a growing concern worldwide. This study investigates the association between mutations in the and genes and fluoroquinolone resistance in UPEC isolates from Urine samples in Iran. In total, 150 UPEC isolates were collected, and then, 12 ciprofloxacin-resistant isolates were selected for molecular analysis.

View Article and Find Full Text PDF

Using the stable synthetic analogue 3-aza-dehydroxylysyl-phosphatidylglycerol (3adLPG), the putative role of native staphylococcal LPG in inhibiting the antibiotic daptomycin from binding to its target phosphatidylglycerol (PG), was investigated with respect to interfacial interactions between these lipids, daptomycin, and calcium ions. The influence of lipid monolayer/bilayer composition and interfacial ion concentrations upon the structure and integrity of model membranes were probed after daptomycin challenge using a combination of surface x-ray scattering techniques and fluorescence assays. In models representing the membrane composition of the daptomycin susceptible phenotype consisting of PG/3adLPG in a 7:3 M ratio, calcium ions drive the formation of two separate phases; Ca cross-linked PG/PG pairs and PG/3adLPG ion pairs.

View Article and Find Full Text PDF

Antimicrobial resistance (AMR) poses a significant global health challenge, impacting humans, animals, and the environment. Dogs and cats are vulnerable to urinary tract infections (UTIs), mostly caused by antimicrobial-resistant Escherichia coli, necessitating antimicrobial susceptibility testing (AST) for optimal treatment. This study investigated and evaluated the seasonality of AST and AMR in urinary E.

View Article and Find Full Text PDF

Antimicrobial resistance (AMR) is a significant public health concern globally, and Pakistan is no exception. The misuse and overuse of antibiotics, inadequate regulation of their sale, and a lack of awareness contribute to the rising levels of AMR in the country. study presents a detailed analysis of blood and urine samples collected in Pakistan over various periods, focusing on pathogen prevalence, gender distribution, and age-wise patterns.

View Article and Find Full Text PDF

Prevalence and molecular characterization of methicillin-resistant Staphylococcus aureus (MRSA) in acute and chronic sinusitis.

Mol Biol Rep

September 2025

Department of Medical Lab Technology, College of health and medical technology, Sulaimani Polytechnic University, Sulaimani, 46001, Kurdistan Region, Iraq.

Background: Sinusitis is a common respiratory infection increasingly associated with antibiotic-resistant Staphylococcus aureus, posing significant treatment challenges. The emergence of methicillin-resistant S. aureus (MRSA) in sinus infections necessitates comprehensive profiling of resistance patterns to guide effective therapy.

View Article and Find Full Text PDF