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http://dx.doi.org/10.1093/rheumatology/keaa572 | DOI Listing |
Cureus
August 2025
Department of Urology, The Institute of Medical Science, The University of Tokyo, Tokyo, JPN.
In patients with advanced urothelial carcinoma who have progressed after platinum-based chemotherapy, enfortumab vedotin (EV) improves overall survival compared to standard chemotherapy. Additionally, for treatment-naïve patients with locally advanced or metastatic urothelial carcinoma, the combination of pembrolizumab and EV demonstrates superior efficacy over platinum-based chemotherapy. Hence, EV becomes a standard treatment option.
View Article and Find Full Text PDFCureus
August 2025
Internal Medicine, Centro Médico Nacional Siglo XXI, Mexico City, MEX.
Acute generalized exanthematous pustulosis (AGEP) is a rare, potentially severe cutaneous adverse reaction characterized by the rapid onset of numerous small, sterile pustules on edematous erythema, commonly accompanied by systemic symptoms such as high-grade fever and neutrophilic leukocytosis. AGEP is most frequently triggered by medications, especially antibiotics, though infections and other exposures can also be causative. We report the case of a previously healthy 27-year-old male patient who developed a febrile pustular eruption with systemic involvement.
View Article and Find Full Text PDFCureus
August 2025
Department of Dermatology, Poznan University of Medical Sciences, Poznan, POL.
Atopic dermatitis (AD) is a chronic inflammatory skin condition often complicated by cardiovascular comorbidities, impacting treatment options and outcomes. In this paper, we present a 41-year-old patient with severe AD, asthma, and chronic heart failure, who responded well to dupilumab, showing significant improvements in skin severity scores and heart function. This case underscores the effectiveness of dupilumab in managing AD alongside complex comorbidities.
View Article and Find Full Text PDFClin Exp Dermatol
September 2025
School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.
Background: Acute generalized exanthematous pustulosis (AGEP) is a rare skin condition often triggered by medications. Many case reports have been published but a few studies on large cohorts have been reported to date.
Objectives: The aim of the current study is to provide correlation between AGEP EuroSCAR score and clinical, laboratory findings and histopathologic examination in a large cohort.
Sci Rep
September 2025
Jining Medical University School of Basic Medicine, Jining, 272067, China.
The causal relationship between vitamin B12 deficiency anaemia and the risk of developing lung diseases remains unclear. This study aimed to clarify that relationship using Mendelian randomization (MR) with Bayesian weighting, focusing on pulmonary fibrosis (PF), idiopathic PF (IPF), eosinophilic asthma (EA), squamous cell lung cancer (LUSC), chronic obstructive pulmonary disease (COPD), and pulmonary embolism (PE). We analysed genome-wide association study (GWAS) data, applied five MR models with Bayesian methods to assess causality, and validated the results via sensitivity analysis.
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