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http://dx.doi.org/10.1590/s1678-9946202062058 | DOI Listing |
Viruses
August 2025
Department of Health Promotion, Mother and Child Care, Internal Medicine, and Medical Specialties "G D'Alessandro", University of Palermo, 90133 Palermo, Italy.
Background: The advent and continuous improvement in antiretroviral therapy (ART) have profoundly altered the clinical course of HIV infection, shifting the focus from AIDS-related complications to the management of age-related comorbidities and non-AIDS-related hospitalizations. In this evolving context, optimizing ART is essential, with genotypic resistance testing (GRT), particularly through next-generation sequencing (NGS), playing a pivotal role.
Methods: This multicenter, retrospective cross-sectional study investigated HIV-1 subtypes, resistance mutations, and drug resistance profiles among 367 people living with HIV (PLWH) in Sicily, based on 384 GRTs performed at the Microbiology Laboratory of the University Hospital of Palermo.
Background: HIV infection is of concern, especially in Sub-Saharan Africa which is home to two thirds (67%) of the total number of people living with HIV (PLHIV) in the world. In Southern Africa, Mozambique ranks second, with about 2.2 million PLHIV.
View Article and Find Full Text PDFAfr Health Sci
June 2025
Makerere University School of Medicine, Department of Paediatrics and Child Health.
Background: Despite several efforts to educate adolescents about HIV/AIDS in Uganda, many still engage in unsafe behaviors, putting them at risk of HIV infection.
Objective: We aimed to assess the level of HIV knowledge and associated factors and establish association with sexual behavior among 13 to 19-year-old adolescents living in an urban division in Kampala district.
Methods: We conducted a cross-sectional study among 976 adolescents selected through multistage sampling and administered one pretested questionnaire to collect data.
BMC Public Health
August 2025
Health Economics Research Unit, Aberystwyth Business School, Aberystwyth University, Aberystwyth, Ceredigion, SY23 3DY, UK.
Background: Although Ghana has made modest progress in the fight against HIV, the prevalence among women remains high, with 66% of people living with HIV in the country being females. Besides, approximately 71% of people with HIV in Ghana know their status compared with the global average of 85% and the WHO target of 95%. This relatively low percentage of people with HIV, knowing their status, tends to derail Ghana's attainment of SDG 3.
View Article and Find Full Text PDFJ Public Health Afr
July 2025
Faculty of Health Sciences, University of Abomey-Calavi, Abomey-Calavi, Benin.
Background: Antimicrobial resistance (AMR) is a significant global public health threat that undermines sustainable development. In Benin, high AMR rates to common antibiotics, including last-resort treatments, exacerbate infection outcomes and healthcare costs. Inappropriate antibiotic use worsens this challenge.
View Article and Find Full Text PDF