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Setting: Outpatient clinics, Kota Kinabalu, Malaysia; January-April 2018.
Objectives: To identify barriers to full participation in tuberculosis (TB) contact investigation.
Methods: Cross-sectional study of knowledge, perceptions, and behaviours among TB contacts. This study was conducted among contacts who attended an initial clinic visit to explore retention in care. During this first visit, contacts were approached for participation in a questionnaire at a follow-up visit. Contacts who consented but did not subsequently attend were interviewed at home. Associations between questionnaire findings and attendance were tested using logistic regression.
Results: Of the total 1436 identified contacts, 800 (56%) attended an initial clinic visit. Of 237 consenting TB contacts, 207 (87%) attended their follow-up appointment. In univariable analyses, the odds of attendance were highest for people notified to attend the TB clinic directly by a health inspector; close relatives of TB patients; non-students; people with higher incomes and smaller households; older individuals; males; and people not perceiving TB as stigmatising. In multivariable analysis, mode of notification to attend and having a close relative with TB remained significant.
Conclusions: Health inspectors provide an effective role in TB contact investigation through direct personal communication to encourage the completion of the TB screening process, but this requires further integration with clinical processes, and with workplace and school-based investigations.
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http://dx.doi.org/10.3390/tropicalmed5030124 | DOI Listing |
Cureus
August 2025
Internal Medicine, Good Shepherd Hospital, Vythiri, IND.
Hypereosinophilic syndrome (HES) is a rare disorder marked by sustained blood eosinophilia and associated tissue or organ damage in the absence of a secondary identifiable cause. Eosinophilic ascites and pleural effusion are extremely rare clinical presentations of idiopathic HES and often mimic malignancy, tuberculosis, or parasitic infections. We report a case of idiopathic HES in a 68-year-old male presenting with exudative eosinophilic ascites and pleural effusion.
View Article and Find Full Text PDFCureus
August 2025
Respiratory Medicine, Sri Ramachandra Institute of Higher Education and Research, Chennai, IND.
Tuberculosis (TB) is a multisystem infectious disease with both pulmonary and extrapulmonary manifestations. TB can also induce a hypercoagulable state, setting off a cascade of changes in the body, including systemic inflammation, endothelial dysfunction, and abnormalities in the coagulation and fibrinolytic pathways. Collectively, these factors significantly increase the risk of venous thromboembolism, such as deep vein thrombosis and pulmonary embolism.
View Article and Find Full Text PDFAesthetic Plast Surg
September 2025
Department of Otolaryngology, Masih Daneshvari Hospital, Neyavran, Darabad, Tehran, Iran.
Nasal alar reconstruction is complex due to the region's anatomy and aesthetic importance. This report describes repairing a small, full-thickness alar rim defect in a 36-year-old man using a rotational columellar skin flap with septal cartilage grafting. This single-stage technique achieved good color match, symmetry, and minimal donor-site morbidity.
View Article and Find Full Text PDFJ Infect Dis
September 2025
Department of Preventive & Social Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.
This prospective cohort study evaluated rifampin pharmacokinetics in pregnant and non-pregnant women with tuberculosis in India. Pregnant women had significantly lower drug exposure, with <20% of the participants achieving target concentrations at any trimester. Findings highlight potential underdosing in pregnancy and underscore the need for dedicated pharmacokinetics studies in pregnancy, and revised rifampin dosing guidelines.
View Article and Find Full Text PDFEur J Clin Pharmacol
September 2025
Department of Clinical Pharmacy and Pharmacology, University of Groningen, and University Medical Center Groningen, Groningen, The Netherlands.
Purpose: Non-adherence to inhaled medication poses a significant clinical and economic burden on patients with respiratory diseases. This narrative review provides an overview of key aspects of hair analysis, in general and specific for inhaled medications, and explores the potential of hair analysis as a novel tool to monitor adherence to inhaled medications.
Methods: PubMed searches were conducted to explore four aspects: (1) mechanisms of (inhaled) drug's systemic absorption and deposition in hair; (2) quantification of drugs in hair; (3) factors impacting (inhaled) drug hair concentrations; and (4) clinical studies assessing inhaled medication adherence through hair analysis.