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http://dx.doi.org/10.1016/j.jacr.2020.06.030 | DOI Listing |
BJS Open
September 2025
Digestive Surgery and Transplantation Department, Toulouse University Hospital Centre, Toulouse, France.
Background: Intraoperative autotransfusion remains underutilized in high-risk haemorrhagic oncological procedures, particularly in liver transplantation for hepatocellular carcinoma. This is because of the theoretical risk of tumour cell reinfusion and dissemination, potentially leading to reduced recurrence-free survival. The aim of this study was to evaluate the impact of intraoperative autotransfusion on recurrence-free survival during liver transplantation for hepatocellular carcinoma.
View Article and Find Full Text PDFSmall
August 2025
Department of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
Hepatocellular carcinoma (HCC) is a highly invasive malignant tumor. Tumor-associated fibroblasts (CAFs) and tumor-associated macrophages (TAMs) play important roles in the invasive process and immune escape of HCC. To overcome these barriers, this work has designed a biomimetic dual-engine nanodisruptor (ZHL@CM) by encapsulating losartan (LST) and Radix Hedysari polysaccharide (HPS) within a zeolitic imidazolate framework (ZIF) and camouflaging the construct with macrophage membranes.
View Article and Find Full Text PDFAnimals (Basel)
August 2025
Faculty of Veterinary Science, Prince of Songkla University, Songkhla 90110, Thailand.
Dugongs (), classified as vulnerable marine mammals, are increasingly impacted by infectious diseases, yet the role of septicemia and disseminated intravascular coagulation (DIC) in their mortality remains uncharacterized. This study aimed to investigate the pathological and microbiological features associated with an acute mortality event in a juvenile dugong during rehabilitation in southern Thailand. Comprehensive histopathological and microbiological analyses were conducted on tissue samples collected postmortem.
View Article and Find Full Text PDFHepatology
September 2025
Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China.
Background And Aims: Portal vein tumor thrombus (PVTT) worsens the prognosis of hepatocellular carcinoma by increasing intrahepatic dissemination and inducing portal vein hypertension. However, the immune characteristics of PVTT remain unclear. Therefore, this study aims to explore the immune microenvironment in PVTT.
View Article and Find Full Text PDFHPB (Oxford)
July 2025
Section of Hepato-Pancreato-Biliary Surgery, Makati Medical Center, Makati, Philippines; Section of Hepatobiliary Pancreatic Surgery, Surgical Oncology, and Minimally Invasive Surgery, St Luke's Medical Center, Quezon City, Philippines; Liver Center, National Kidney and Transplant Institute, Quezon
Background: Approximately 80 % of primary liver cancer cases happen in Asia-Pacific and become the leading cause of cancer-related mortality. However, there is no consensus on defining and standardizing the optimal management of large HCCs.
Methods: The Asia-Pacific Consensus Conference employed the Modified Delphi method, consisting of three rounds of surveys followed by a discussion panel.