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A 30-year-old male after consuming alcohol and drugs lost consciousness and passed out in his bathroom. After 10 hours, he was found immobilized stuporous on his bathroom floor and brought by emergency service to the emergency room. He was found to have compartment syndrome of the right lower limb and underwent emergency fasciotomy of three compartments of the thigh and four compartments of the leg. The postoperative course was complicated by acute kidney injury necessitating hemodialysis. On postoperative day three from the index fasciotomy patient was found to develop foot compartment syndrome despite not having foot compartment involved in the initial presentation. In opioid abuse, patients' additional compartments can get involved during the disease process, and it is essential to identify them with regular physical examination and use of biomarkers.
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http://dx.doi.org/10.7759/cureus.8628 | DOI Listing |
PLoS One
September 2025
Department of Nephrology, Chungnam National University, Daejeon, Republic of Korea.
Diabetic kidney disease (DKD) involves oxidative stress-driven damage to glomeruli (Gloms) and proximal convoluted tubules (PCT). NAD(P)H: quinone oxidoreductase 1 (NQO1) regulates redox balance, but its compartment-specific role remains unclear. Streptozotocin (STZ)-induced hyperglycemia increased albuminuria and foot process effacement, with NQO1 KO (NKO) mice exhibiting greater podocyte injury than WT, indicating exacerbated glomerular damage.
View Article and Find Full Text PDFMicrosurgery
September 2025
Department of Plastic and Reconstructive Surgery, MedStar Georgetown University Hospital, Washington, DC, USA.
Background: Patients with only peroneal artery blood supply to the foot, known as peronea arteria magna (PAM), represent a rare cohort and a unique challenge in the setting of complex lower free (LE) tissue transfer (FTT). The present study aims to leverage a high volume lower extremity reconstruction center to determine the incidence and microsurgical considerations in PAM.
Methods: A retrospective cohort study was conducted at a single tertiary limb salvage center, reviewing all patients who underwent lower LE FTT from July 2011 to January 2024.
Mol Cell Proteomics
August 2025
Dr. Philip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine; Miami, Florida, United States. Electronic address:
Chronic wounds such as diabetic foot ulcers (DFUs) and venous leg ulcers (VLUs) are a growing public health burden, contributing to significant morbidity, healthcare costs, and mortality. Current management strategies are hampered by the inability to accurately predict healing trajectories or identify early treatment failures. Here, we present a novel, non-invasive proteomic approach that leverages routinely discarded wound dressings to profile the wound microenvironment across soluble, cellular, and extracellular vesicle (EV) compartments.
View Article and Find Full Text PDFJ Orthop Res
August 2025
Meinig School of Biomedical Engineering, Cornell University, Ithaca, New York, USA.
Patients with cartilage defects often experience increased meniscal degeneration. It remains unclear whether meniscal damage occurs concurrently with cartilage injury or due to later joint pathology. Limited data exists on how isolated cartilage injuries affect meniscal structure and degeneration.
View Article and Find Full Text PDFLancet Rheumatol
August 2025
Musculoskeletal Research Laboratory, Veterans Affairs Palo Alto Healthcare System, Palo Alto, CA, USA; Bioengineering, Stanford University, Stanford, CA, USA.
Background: Retraining individuals with medial compartment knee osteoarthritis to walk with a patient-specific change in their foot angle (ie, toe-in or toe-out angle) can reduce excessive joint loading related to disease progression. This study investigated the clinical, biomechanical, and structural efficacy of personalised foot progression angle modifications compared with sham treatment in patients with mild-to-moderate medial compartment knee osteoarthritis.
Methods: In this single-center, parallel-group, randomised controlled trial, we recruited individuals with symptomatic medial compartment knee osteoarthritis at the Human Performance Laboratory and Lucas Center for Imaging at Stanford University, CA, USA, using online and print media.