Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
The effects of three hydrophilic polymers, namely, carboxymethyl cellulose sodium (CMC-Na), polyvinyl alcohol (PVA) and poloxamer-188 (PXM-188) on the solubility and dissolution of diflunisal (DIF) in complexation with β-cyclodextrin (βCD) or hydroxypropyl β-cyclodextrin (HPβCD), were investigated. The kneading method was used at different drug to cyclodextrin weight ratios. Increases in solubility and drug release were observed with the DIF/βCD and DIF/HPβCD complexes. The addition of hydrophilic polymers at 2.5, 5.0 and 10.0% w/w markedly improved the complexation and solubilizing efficiency of βCD and HPβCD. Fourier-transform infrared (FTIR) showed that DIF was successfully included into the cyclodextrin cavity. Differential scanning calorimetry (DSC) and X-ray diffractometry (XRD) confirmed stronger drug amorphization and entrapment in the molecular cage of cyclodextrins. The addition of PVA, CMC-Na or PXM-188 reduced further the intensity of the DIF endothermic peak. Most of the sharp and intense peaks of DIF disappeared with the addition of hydrophilic polymers. In conclusion, PXM-188 at a weight ratio of 10.0% w/w was the best candidate in enhancing the solubility, stability and release of DIF.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408593 | PMC |
| http://dx.doi.org/10.3390/polym12071564 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Hydrophilic Polymer Embolism and Silent Brain Injury: An Underexplored Connection.
Cardiovasc Intervent Radiol
September 2025
Neuroradiologische Klinik, Kopf- Und Neurozentrum, Klinikum Stuttgart, Kriegsbergstraße 60, 70174, Stuttgart, Germany.
Facial Asymmetry in the Helical Grooves of Chiral Helical Polymers to Create 2D Single-Chain Archimedean Spiral Nanostructures.
ACS Nano
September 2025
CINBIO and Departamento de Química Orgánica. Campus Lagoas-Marcosende, Universidade de Vigo, Vigo E-36310, Spain.
Archimedean spirals are architectural motifs that are found in nature. The facial asymmetry of amphiphilic molecules or macromolecules has been a key parameter in the preparation of these well-organized two-dimensional nanostructures in the laboratory. This facial asymmetry is also present in the helical grooves of chiral helical substituted poly(phenylacetylene)s (PPAs) and poly(diphenylacetylene)s (PDPAs), making them excellent candidates for self-assembly into 2D Archimedean nanospirals or nanotoroids.
View Article and Find Full Text PDFUrinary catheters: state of the art and future perspectives - a narrative review.
Mater Today Bio
October 2025
University of Maribor, Faculty of Medicine, Institute of Biomedical Sciences, Taborska Ulica 8, SI-2000, Maribor, Slovenia.
Catheter associated urinary tract infection (CAUTI) is the most frequent healthcare associated infection, arising from microbial adhesion to catheter surfaces, biofilm development, and the growing problem of antimicrobial resistance. Many publications have addressed CAUTI epidemiology, biofilm biology, or biomaterials for catheters in isolation, yet there is little literature that connects these areas into a coherent translational perspective. This review seeks to fill that gap by combining an overview of biofilm pathophysiology with recent advances in material based innovations for catheter design, including nanostructured and responsive coatings, sensor enabled systems, additive manufacturing, and three dimensional printing.
View Article and Find Full Text PDFFunctionalized hyaluronic acid biomaterials-encouraged cancer immunotherapy through CD44-mediated targeting and cell surface engineering: A review.
Int J Biol Macromol
September 2025
Department of Chemical & Biochemical Engineering, Dongguk University, Seoul, 04620, Republic of Korea. Electronic address:
Modified hyaluronic acid (HA) biomaterials have received considerable attention in recent years, especially in developing innovative therapeutic strategies for targeted disease interventions. HA serves to shield therapeutics from the physiological environment, while enabling safe delivery and promoting uptake into specific cells. As a hydrophilic chain polymer, HA is readily chemically modified into functional biomaterials for drug delivery and cancer immunotherapy.
View Article and Find Full Text PDFIn-the-Bag Behavior of a New Aspheric Hydrophobic Acrylic Toric Intraocular Lens.
J Refract Surg
September 2025
Purpose: To evaluate tilt, decentration, and axial stability of the Clareon toric intraocular lens (TIOL) (CNW0T3-9; Alcon Laboratories, Inc) over a 6-month follow-up period.
Methods: A single-center, prospective, interventional clinical trial was conducted with a study population of 130 eyes from 82 patients who received a Clareon TIOL. Tilt, decentration, and the aqueous depth were determined preoperatively and at 1 week and 6 months postoperatively using anterior segment optical coherence tomography (Casia 2; Tomey Corporation).