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http://dx.doi.org/10.21037/jtd.2020.03.113 | DOI Listing |
Background And Objectives: Thymidine kinase 2 deficiency (TK2d) is an ultra-rare, progressive, and life-threatening mitochondrial myopathy caused by pathogenic variants of the thymidine kinase 2 gene. Patients often lose the ability to walk, eat, and breathe independently. There are no approved therapies; however, preclinical studies of pyrimidine nucleos(t)ide therapy have shown promising results.
View Article and Find Full Text PDFEur J Pediatr
September 2025
Pediatric Department, Alexandria University Hospital, Alexandria, Egypt.
The objective was to evaluate the effect of nebulized nitroglycerin (NNG) in neonates with persistent pulmonary hypertension (PPHN). The study focused on assessing changes in echocardiographic and clinical parameters following its administration. This is a randomized controlled trial that included 80 full-term newborns diagnosed with PPHN within 72 h after birth.
View Article and Find Full Text PDFJ Cardiothorac Vasc Anesth
August 2025
Anesthesiology Department, Hôpitaux Universitaires de Bruxelles-Site Erasme, Bruxelles, Belgium.
Objective: To evaluate in cardiac surgery patients the potential for alveolar recruitment at 3 perioperative time points-after intubation, after cardiopulmonary bypass (CPB), and on arrival in the intensive care unit (ICU)-by collecting pulmonary compliance values and calculating the recruitment-to-inflation (R/I) ratio.
Design: An interventional cohort single-center study conducted in a department of anaesthesiology and critical care and an ICU SETTING: This interventional study was conducted in 41 patients undergoing noncomplex cardiac surgery. Ventilatory mechanics, blood gas analysis, and hemodynamic parameters were measured before, during, and after a lung recruitment maneuver (LRM) (3 minutes at a positive end-expiratory pressure [PEEP] of 12 cmHO).
World J Crit Care Med
September 2025
Department of Anaesthesiology and Critical Care, Medical Trust Hospital, Ernakulam 682016, Kerala, India.
Background: Lung ultrasonography is being increasingly used in mechanically ventilated patients to evaluate the lung aeration during incremental positive end expiratory pressure (PEEP) adjustments and to evaluate the weaning process from mechanical ventilation. The effects of PEEP may vary across different lung pathologies and may not consistently correlate with changes in lung aeration as assessed by lung ultrasound scores (LUSs).
Aim: To assess the role of lung ultrasonography in evaluating lung aeration during the application of PEEP in mechanically ventilated patients with various lung pathologies.
Eur J Anaesthesiol
August 2025
From the Department of Intensive Care, Amsterdam University Medical Centres, location AMC, Amsterdam, The Netherlands (RLG, DMPvM, FP, MJSS), Department of Anaesthesia and Intensive Care, IRCCS Ospedale Policlinico San Martino, Genoa, Italy (SG, SD, LB, NAP, CR), Department of Anaesthesiology, Amste
Background: Invasive ventilation can be challenging in acute brain injury (ABI) patients as partial pressure of carbon dioxide and oxygen need to be kept in precise optimal ranges while simultaneously applying lung-protective ventilation. Fully automated ventilation may be effective in achieving protective ventilation targets for brain and lung.
Objectives: To compare automated ventilation to conventional ventilation for ABI patients.