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Article Abstract
Benzimidazoles are important -heteroaromatic compounds with various biological activities and pharmacological applications. Herein, we present the first iron-catalyzed selective synthesis of 1,2-disubstituted benzimidazoles acceptorless dehydrogenative coupling of primary alcohols with aromatic diamines. The tricarbonyl (η-cyclopentadienone) iron complex catalyzed dehydrogenative cyclization, releasing water and hydrogen gas as by-products. The earth abundance and low toxicity of iron metal enable the provision of an eco-friendly and efficient catalytic method for the synthesis of benzimidazoles.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317090 | PMC |
| http://dx.doi.org/10.3389/fchem.2020.00429 | DOI Listing |
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