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http://dx.doi.org/10.1016/j.jaci.2020.05.049 | DOI Listing |
Curr Opin Allergy Clin Immunol
August 2025
Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark.
Purpose Of Review: The potential of allergen immunotherapy (AIT) to prevent allergic airway disease progression are demonstrated. Though not all patients benefit equally, there is limited research on which patients may benefit most.In this article, we focus on factors that may influence the risk of progression and their influence on the preventive effects of AIT, and whether some patients may benefit more than others may.
View Article and Find Full Text PDFClin Exp Immunol
September 2025
Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA.
Chronic rhinosinusitis with nasal polyps (CRSwNP) is an inflammatory disorder of the sinonasal mucosa, predominantly characterized by epithelial dysfunction and chronic heterogeneous mucosal inflammation. CRSwNP and asthma are common comorbidities with overlapping pathophysiology, epithelial impairment and activation of downstream type 2 inflammation. Thymic stromal lymphopoietin (TSLP) is an epithelial cytokine that sits at the top of the immunological cascade and initiates and amplifies type 2-dependent and -independent inflammatory responses.
View Article and Find Full Text PDFCureus
August 2025
Allergy and Immunology, Wilford Hall Medical Center, San Antonio, USA.
We present two patients who presented with symptoms that overlap with asthma, but upon further diagnostic evaluation, were revealed to have underlying malignancy. These cases highlight the importance of objective evidence-based evaluation in unveiling diagnoses previously mislabeled as asthma. The first patient was a 51-year-old with one year of cough and waning albuterol responsiveness, with worsening orthopnea and exertional dyspnea.
View Article and Find Full Text PDFCureus
August 2025
Department of Anaesthesiology, Hebrew University of Jerusalem, Faculty of Medicine, Jerusalem, ISR.
Pregnancy in women with Ehlers-Danlos syndrome (EDS) carries elevated risks, including prematurity, hemorrhage, and maternal morbidity, posing significant anesthetic challenges. We present the case of a 36-year-old woman with classical EDS (cEDS) and multiple comorbidities, including postural orthostatic tachycardia syndrome, bronchial asthma, congenital adrenal hypoplasia, and chronic venous thrombosis, who underwent an elective cesarean section. A multidisciplinary team developed a comprehensive perioperative plan featuring ultrasound-guided spinal anesthesia, extended post-anesthesia observation, and coordinated recommendations from cardiology, hematology, endocrinology, pulmonology, and other specialties.
View Article and Find Full Text PDFFront Allergy
August 2025
Department of Pediatrics, Peking University Third Hospital, Beijing, China.
Introduction: Food-induced anaphylactic shock is the most severe and life-threatening manifestation of food allergy in children. However, its underlying risk factors remain poorly defined, especially in pediatric populations. This study aimed to identify independent predictors of food-induced anaphylactic shock by analyzing clinical and immunological data from a tertiary hospital in Northern China.
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