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| http://dx.doi.org/10.1016/j.jgar.2020.06.008 | DOI Listing |
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Novel Class 1 Integron Structures in High-Risk Metallo-β-Lactamase-Producing Pseudomonas aeruginosa ST235 and ST654 From Companion Animals.
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Department of Veterinary Microbiology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand.
Introduction: Carbapenemase-producing Pseudomonas aeruginosa (CP-Pa) has emerged as a significant clinical and public health concern due to its ability to limit treatment options with last-resort antimicrobials. This study aims to characterise novel class 1 integron (Int1) structures containing bla and bla in high-risk CP-Pa sequence type (ST) 235 and ST654 strains from dogs and cats and illustrate the genetic relatedness between CP-Pa strains from animal and human origins.
Methods And Results: Of the four CP-Pa strains, whole-genome sequencing and analysis revealed that three strains belonged to ST235/O11/exoU+/exoS-, with two strains harbouring bla, and one strain harbouring bla.
Import of global high-risk clones is the primary driver of carbapenemase-producing in Norway.
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Norwegian Centre for Detection of Antimicrobial Resistance, Department of Microbiology and Infection Control, University Hospital of North Norway, Tromsø, Norway.
Infections by carbapenemase-producing (CP-Pa) are concerning due to limited treatment options. The emergence of multidrug-resistant (MDR) high-risk clones is an essential driver in the global rise of CP-Pa. Insights into the molecular epidemiology of CP-Pa are crucial to understanding its clinical and public health impact.
View Article and Find Full Text PDF-producing ST654 comprises a quarter of all carbapenem-resistant in blood isolates from 15 hospitals.
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National Institute for Antibiotic Resistance and Infection Control, Ministry of Health, Tel Aviv, Israel.
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- Carbapenem-resistant Pseudomonas aeruginosa (CRPA) poses a significant clinical threat; a study analyzed 85 blood isolates from Israel to evaluate their prevalence and resistance traits.
- 43.5% of the isolates belonged to high-risk clones, with a notable clade (27.1%) linked to the ST654 clone, demonstrating widespread resistance to antibiotics like tobramycin and ceftolozane/tazobactam.
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Isolation of an Extensively Drug-Resistant Pseudomonas aeruginosa /O4 Strain Belonging to the "High-Risk" Clone ST654 and Coproducer of NDM-1 and the Novel VIM-80.
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Detection and characterisation of 16S rRNA methyltransferase-producing Pseudomonas aeruginosa from the UK and Republic of Ireland from 2003-2015.
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National Institute for Health Research Health Protection Research Unit (NIHR HPRU) in Healthcare Associated Infections and Antimicrobial Resistance, Department of Infectious Disease, Imperial College London, London W12 0NN, UK; Antimicrobial Resistance and Healthcare Associated Infections Reference
16S rRNA methyltransferase (16S RMTase) genes confer high-level aminoglycoside resistance, reducing treatment options for multidrug-resistant Gram-negative bacteria. Pseudomonas aeruginosa isolates (n = 221) exhibiting high-level pan-aminoglycoside resistance (amikacin, gentamicin and tobramycin MICs ≥64, ≥32 and ≥32 mg/L, respectively) were screened for 16S RMTase genes to determine their occurrence among isolates submitted to a national reference laboratory from December 2003 to December 2015. 16S RMTase genes were identified using two multiplex PCRs, and whole-genome sequencing (WGS) was used to identify other antibiotic resistance genes, sequence types (STs) and the genetic environment of 16S RMTase genes.
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