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Article Abstract
Objective: Pit and fissure sealants with antibacterial and remineralization properties have broad application prospects in caries prevention. The objectives of this study were to: (1) develop a novel pit and fissure sealant containing CaF nanoparticles (nCaF) and dimethylaminohexadecyl methacrylate (DMAHDM); and (2) investigate the effects of nCaF and DMAHDM on biofilm response and fluoride (F) ion release for the first time.
Methods: Helioseal F was used as a control. Bioactive sealants were formulated with DMAHDM and nCaF. Flow properties, enamel shear bond strength, hardness and F ion releases were measured. Streptococcus mutans (S. mutans) biofilms were grown on sealants. Biofilm metabolic activity, lactic acid production, colony-forming units (CFU), and pH of biofilm culture medium were measured.
Results: Adding 5% DMAHDM and 20% nCaF did not reduce the paste flow and enamel bond strength, compared to control (p < 0.05). Hardness of sealants with 20% nCaF and DMAHDM was higher than control (p < 0.05). The F ion release from 20% nCaF was much higher than that of commercial control (p < 0.05). The sealant with DMAHDM reduced the S. mutans biofilm CFU by 4 logs. The pH in biofilm medium of the new bioactive sealant was much higher (pH 6.8) than that of commercial sealant (pH 4.66) (p < 0.05).
Significance: The new bioactive pit and fissure sealant with nCaF and DMAHDM achieved high fluoride release and strong antibacterial performance. This novel fluoride-releasing and antibacterial sealant is promising to inhibit caries and promote the remineralizaton of enamel and dentin.
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| http://dx.doi.org/10.1016/j.dental.2020.05.010 | DOI Listing |
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