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http://dx.doi.org/10.1016/j.ejrad.2020.109122 | DOI Listing |
Ann Neurol
September 2025
Department of Radiology, Mayo Clinic, Rochester, MN, USA.
Objective: The objective of this study was to determine the predictive value of amyloid-positron emission tomography (PET) versus the plasma ratio of phosphorylated tau at threonine 217 (p-tau217) to non-phosphorylated tau217 (%p-tau217) for tau-PET transitions (T- to T+). The added value of combining plasma amyloid-β 42 and amyloid-β 40 (Aβ42/40) and %p-tau217 into an amyloid probability score (APS2) was also assessed.
Methods: Mayo Clinic Study of Aging (MCSA) participants had plasma markers measured at via mass spectrometry (MS), an amyloid-PET scan, and a tau-PET (meta-temporal region of interest [ROI]) negative scan (standardized uptake value ratio [SUVR] <1.
ACS Electrochem
September 2025
School of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, UK.
The study of electrochemical oxidations has wide-ranging implications, from the development of new electrocatalysts for fuel cells for energy conversion, to the synthesis of fine chemicals. 2,2,6,6-Tetramethylpiperidine-1-oxyl (TEMPO) has been used for decades as a sustainable, metal-free mediator for chemical oxidations and is now being used for electrochemical oxidations. We describe here a novel approach to TEMPO-mediated electrooxidations, in which the chemical input and waste generated during electrooxidations of alcohols are minimized by using a multifunctional room temperature ionic liquid (RTIL) to facilitate flow electrosynthesis.
View Article and Find Full Text PDFBeilstein J Org Chem
August 2025
Department of Chemistry, Institute of Natural Sciences, Federal University of Lavras, 37200-900, Lavras, MG, Brazil.
Cyclopropane is a significant alicyclic motif, widely utilized in medicinal chemistry, while fluorination serves as a powerful tool to modulate properties that enhance the performance of pharmaceuticals and materials. This quantum-chemical study explores the energetic implications of fluorinating cyclopropane, providing insights into molecular characteristics arising from the polar C-F bond. Isodesmic reactions revealed that the conversion of cyclopropane and methyl fluoride into mono-, di-, tri-, tetra-, penta-, and hexafluorinated cyclopropanes is exothermic, except for the all--1,2,3-trifluorocyclopropane ().
View Article and Find Full Text PDFVet World
July 2025
Laboratory of Theriogenology Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan.
Background And Aim: Mycotoxin contamination in poultry feed, particularly with aflatoxin B1 (AFB1) and ochratoxin A (OTA), poses significant threats to broiler health, meat quality, and consumer safety. Toxin binders are commonly used to mitigate these effects; however, their impact on endogenous stem cell activity and overall broiler performance remains underexplored. This study aimed to evaluate the efficacy of a commercial toxin binder in reducing AFB1 and OTA residues in broiler meat, inducing endogenous stem cell production, and improving growth and feed performance indices.
View Article and Find Full Text PDFVet World
July 2025
Department of Nutrition and Feed Technology, Faculty of Animal Science, IPB University, Jl. Agatis, Dramaga Bogor, West Java, Indonesia.
Background And Aim: The global ban on antibiotic growth promoters (AGPs) in poultry production has intensified the search for effective phytogenic alternatives. Roxb., commonly known as Javanese turmeric, exhibits antimicrobial and antioxidant properties attributed to its bioactive compounds, including xanthorrhizol and curcumin.
View Article and Find Full Text PDF