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http://dx.doi.org/10.1016/j.clinre.2020.03.018 | DOI Listing |
Exp Clin Transplant
August 2025
>From the Division of Transplant Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; and the Sackler School of Medicine at Tel Aviv University, Tel Aviv, Israel.
Objectives: On-site normothermic machine perfusion of the liver may require hepatic arterial reconstruction. The effect of arterial reconstruction on the deve-lopment of primary ischemic cholangiopathy has not been fully elucidated in liver transplants with organs donated after circulatory death. The aim of this study was to evaluate the effect of normothermic machine perfusion with arterial reconstruction at the onset of ischemic cholangiopathy in liver transplants with organs donated after circulatory death.
View Article and Find Full Text PDFClin Transplant
August 2025
Recanati/Miller Transplantation Institute, The Mount Sinai Hospital, New York, New York, USA.
Introduction: Normothermic machine perfusion (NMP) is increasing the safe utilization of donation after circulatory death livers. Historically, tissue plasminogen activator (tPA) has been administered intraoperatively to DCD graft recipients to reduce non-anastomotic biliary complications (NAS). Treating the liver during NMP offers a potentially safer administration, preventing systemic treatment of the recipient.
View Article and Find Full Text PDFCholestasis, or disruption in bile flow, is a common yet poorly understood feature of many liver diseases and injuries. Despite this, many engineered human tissue models of liver disease fail to recapitulate physiological bile flow. Here, we present a 3D multicellular spheroid-based model of the human hepatobiliary junction, the interface between hepatocytes and cholangiocytes often disrupted in liver disease that is required for directing bile excreted by hepatocytes into the biliary ductal system.
View Article and Find Full Text PDFJ Am Coll Surg
July 2025
Department of Surgery, Division of Liver and Pancreas Transplantation, David Geffen School of Medicine at UCLA - Los Angeles, CA.
Background: Biliary tract obstruction (BTO) is a common complication following liver transplantation (LT) with high potential for morbidity. A comprehensive assessment of post-LT BTO, including patient and intraoperative characteristics predictive of postoperative obstruction, remains lacking.
Study Design: A prospectively collected database of all LTs performed at a single-center institution from 2014-2022 was analyzed.
Cureus
June 2025
Transplant Surgery, Medical College of Wisconsin, Milwaukee, USA.
Celiac artery aneurysm is a rare entity among the visceral artery aneurysms, with a high risk of rupture, resulting in high mortality. Arterial complications, such as thrombosis, dissection, and hemorrhage, are among the most serious complications after liver transplantation (LT), which can lead to abscess formation, ischemic cholangiopathy, and hepatic ischemia and necrosis. Therefore, an adequate inflow of the hepatic artery is crucial to avoid any occlusion after LT.
View Article and Find Full Text PDF