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We report direct atomic-force-microscope measurements of capillary force hysteresis (CFH) of a circular contact line (CL) formed on a long glass fiber, which is coated with a thin layer of soft polymer film and intersects a water-air interface. The measured CFH shows a distinct overshoot for the depinning of a static CL, and the overshoot amplitude grows logarithmically with both the hold time τ and fiber speed V. A unified model based on the slow growth of a wetting ridge and force-assisted barrier crossing is developed to explain the observed time (or state) and speed (or rate) dependent CL depinning dynamics over an aging soft surface. The experimental findings have important implications to a common class of problems involving depinning dynamics in a defect or roughness landscape, such as friction of solid interfaces.
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http://dx.doi.org/10.1103/PhysRevLett.124.188003 | DOI Listing |
J Med Chem
September 2025
Faculty of Mathematics and Natural Sciences, Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany.
New treatment strategies are required to combat the spread of drug-resistant malaria. The synthesis and preclinical evaluation of novel 3-hydroxy-propanamidines (HPAs), with modifications of the phenanthrene and the 4-fluorobenzamidine moieties, has yielded several analogs exhibiting excellent in vitro growth inhibition of drug-sensitive or resistant fresh clinical isolates and culture-adapted strains. No cytotoxicity in the human HepG2 cell line was observed, demonstrating notable parasite selectivity.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
September 2025
Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853.
Ovulation is an intricate process that is essential for reproductive success. In , ovulation increases after mating. This increase is initiated by the male seminal fluid protein ovulin and is executed by female pathways, including octopamine (OA) neuronal signaling.
View Article and Find Full Text PDFAdv Physiol Educ
September 2025
Swansea University Medical School, Swansea University, Swansea, UK.
The chick embryo ventricular cardiomyocyte model provides students easy access to experiments involving fundamental features of cardiac cell physiology and pharmacology. Using standard physiology teaching laboratories and basic cell culture equipment, spontaneously beating colonies of electrically-connected cardiomyocytes can be obtained by the students themselves. Students learn, aseptic techniques and cell culture alongside experiments illustrating, at the simplest level of experimentation, how beating rate can be altered physiologically or pharmacologically.
View Article and Find Full Text PDFEnviron Sci Technol
September 2025
Fujian Provincial Key Laboratory of Soil Environmental Health and Regulation, College of Resources and Environment, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Iron plaque (IP) on rice root surfaces has been extensively documented as a natural barrier that effectively reduces contaminant bioavailability and accumulation. However, its regulatory mechanisms in rhizospheric methane oxidation and biological nitrogen fixation (BNF) remain elusive. This study reveals a previously unrecognized function of IP: mediating methanotrophic nitrogen fixation through coupled aerobic methane oxidation and IP reduction (Fe-MOX).
View Article and Find Full Text PDFJAMA Netw Open
September 2025
Division of Cardiology, Department of Internal Medicine, New Taipei Municipal TuCheng Hospital, New Taipei, Taiwan.
Importance: The cardiovascular benefits of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) may vary by body mass index (BMI), but evidence on BMI-specific outcomes remains limited.
Objective: To investigate the associations of GLP-1 RA use with cardiovascular and kidney outcomes across BMI categories in patients with type 2 diabetes.
Design, Setting, And Participants: This retrospective cohort study used the Chang Gung Research Database, a clinical dataset covering multiple hospitals in Taiwan.