Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/eurheartj/ehaa428 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Improving central apnea detection in preterm infants: Neural network strategies and clinical impact.
Comput Methods Programs Biomed
August 2025
Electrical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.
Background And Objective: Preterm infants are characterized by immature cardiorespiratory systems and require continuous monitoring of physiological signals in neonatal intensive care units (NICUs) to assess their clinical condition and return alarms in critical situations. However, many alarms are false or clinically irrelevant, leading to alarm fatigue for nurses and clinicians. A particularly high false alarm rate is reported for central apneas (CAs), with precision as low as 0.
View Article and Find Full Text PDFRationale and Design of the Comparative Effectiveness of ICD Versus Non-ICD Therapy in Contemporary Heart Failure Patients at a Low Risk for Arrhythmic Death (CONTEMP-ICD) trial.
Am Heart J
September 2025
Baylor Scott and White Research Institute and HealthCare, Dallas TX. Electronic address:
Background: Current recommendations for a prophylactic (primary prevention) implantable cardioverter defibrillator (ICD) in patients with both ischemic and non-ischemic heart failure with reduced ejection fraction (HFrEF) originate from clinical trials conducted in selected patients over 20 years ago that showed an overall statistically significant survival benefit associated with a primary prevention ICD in the range of 23%-34%. The recent introduction of angiotensin receptor-neprilysin inhibitors [ARNI] and sodium glucose co-transporter 2 inhibitors [SGLT2i]) was shown to further reduce the risk of sudden cardiac death (SCD) in patients with HFrEF. Thus, there is an unmet need appropriately designed comparative effectiveness clinical trials aimed to reassess the survival benefit of a primary prevention ICD in contemporary patients with HFrEF.
View Article and Find Full Text PDFTranscriptional regulation in heart development, disease and regeneration: reassessing the fetal gene hypothesis.
Nat Rev Cardiol
September 2025
Murdoch Children's Research Institute, The Royal Children's Hospital, Melbourne, Victoria, Australia.
A central paradigm in cardiac biology is the reactivation of the fetal gene programme in the adult heart in response to stress. This so-called 'fetal gene hypothesis' was first proposed almost 40 years ago following the observation that certain fetal contractile protein isoforms were re-expressed in hypertrophied ventricles in the rodent heart in response to haemodynamic overload. Consequently, this concept was broadly adopted, and activation of the fetal gene programme became synonymous in the literature with the cardiac stress response.
View Article and Find Full Text PDFA Rare Case of Single Coronary Artery With Pulmonary Artery Fistula.
JACC Case Rep
September 2025
Meyer University Hospital, Florence, Italy.
Background: Single coronary artery is a rare congenital anomaly. Its coexistence with coronary artery fistula is exceedingly uncommon.
Case Summary: A 61-year-old woman with no cardiovascular risk factors underwent her first cardiological evaluation after incidental detection of atrial fibrillation.
Antifungal echinocandins: Historical discovery, comprehensive structure-activity relationships, resistance mechanisms and future developments.
Eur J Med Chem
August 2025
Chemobiology and Pharmacognosy for Health (CPS) Team, Strasbourg Institute for Drug Discovery and Development (ITI IMS), Laboratory of Therapeutic Innovation (LIT), UMR 7200 CNRS/Unistra, Faculty of Pharmacy, 74, route du Rhin, Illkirch, 67400, France; University of Strasbourg Institute for Advanced
Before the 2000s, the antifungal toolbox against invasive fungal infections (IFIs) was only composed of very toxic amphotericin B, weakly selective and nearly unused 5-fluorocytosine and azoles that have been massively used in agriculture and horticulture. The emergence of resistances followed their respective launch, so many antifungals became progressively inefficient whereas the antifungal research was left behind. In the 2000s, echinocandins (ECs) were introduced as a new antifungal class of natural origin and of unprecedented mechanism of action.
View Article and Find Full Text PDF