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http://dx.doi.org/10.1513/AnnalsATS.202005-427RL | DOI Listing |
Perfusion
September 2025
Department of Adult Critical Care, Guy's and St Thomas' NHS Foundation Trust, London, UK.
IntroductionWe report the successful use of erector spinae (ESP) plane block in the management of a patient with severe respiratory failure secondary to chest trauma requiring invasive ventilation and Veno-venous extracorporeal membrane oxygenation (V-V ECMO).Case reportA 64-year-old man with flail chest and severe respiratory failure required V-V ECMO. An ESP plane block on day 3 enabled extubation, mobilisation, and secretion clearance, leading to ECMO weaning after six days and discharge 18 days post-injury.
View Article and Find Full Text PDFCrit Care Explor
September 2025
Division of Pulmonary, Allergy, Critical Care, and Sleep, University of Minnesota, Minneapolis, MN.
Mean airway pressure, a monitored variable continuously available on the modern ventilator, is the pressure measured at the airway opening averaged over the time needed to complete the entire respiratory cycle. Mean airway pressure is well recognized to connect three key physiologic processes in mechanical ventilation: physical stretch, cardiovascular dynamics, and pulmonary gas exchange. Although other parameters currently employed in adults to determine "safe" ventilation are undoubtedly valuable for daily practice, all have limitations for continuous monitoring of ventilation hazard.
View Article and Find Full Text PDFRadiol Cardiothorac Imaging
October 2025
Edinburgh Imaging and Centre for Cardiovascular Science, Queens Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom.
Functional thoracic MRI provides regional assessment of the three principal components of lung function: ventilation, perfusion, and gas exchange. It offers advantages over pulmonary function tests like spirometry, which yield only global measurements. MRI enables comprehensive evaluation of respiratory mechanics, including chest wall and diaphragm motion, dynamic large airway instability, and lung ventilation using various contrast mechanisms and gas agents.
View Article and Find Full Text PDFEur J Anaesthesiol
September 2025
From the Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA (AZV), Department of Anesthesiology, Hospital Universitario Evaristo Garcia, Universidad del Valle, Cali, Colombia (AZV), Department of Anesthesiology and Critical Care, H
Background: Individualisation of positive-end expiratory pressure (PEEP) is an open-lung ventilation strategy associated with better respiratory mechanics. Mechanical power has been associated with lung injury in critical care settings, but the interaction between optimisation of PEEP and mechanical power during one-lung ventilation (OLV) remains poorly understood.
Objective: This study aimed to determine the effect of individualisation of PEEP on mechanical power during OLV as well as to establish the association between mechanical power and postoperative pulmonary complications after thoracic surgery.
ACS Nano
September 2025
Department of Chemical and Biological Engineering, Korea University, Seoul 02841, Republic of Korea.
Pulmonary fibrosis is a life-threatening disorder characterized by excessive extracellular matrix (ECM) deposition and progressive dysfunction. The disease progression is closely associated with increased ECM stiffness, which compromises normal tissue mechanics and leads to respiratory failure. Although its etiology is multifactorial, immune-mediated responses are central drivers of fibrotic remodeling through inflammatory cytokine release and aberrant tissue repair.
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