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Am J Public Health
October 2025
Joseph Keawe'aimoku Kaholokula is a professor and chair of Native Hawaiian Health at the John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu.
Breast J
September 2025
University of Hawai'i Cancer Center, Honolulu, Hawaii, USA.
The Oncotype DX test is standardly used for patients with early-stage, hormone-receptor-positive, HER2-negative breast cancers to determine the benefit from chemotherapy and the likelihood of distant recurrence. The relationship between Oncotype DX recurrence scores and race/ethnicity is still being studied. This retrospective study aims to evaluate the relationship between Oncotype DX recurrence scores, race/ethnicity, and clinicopathological factors and to support the applicability of the Oncotype DX test for a diverse breast cancer population of Hawaii.
View Article and Find Full Text PDFCommun Biol
September 2025
Division of Neurobiology, Faculty of Biology, Ludwig-Maximilians-Universität München, Planegg - Martinsried, Germany.
The internal resistance of axons to ionic current flow determines action potential conduction velocity. Although mitochondria support axonal function, axons have been modeled as organelle-free cables, and mitochondrial impact on conduction velocity, specifically by increasing internal resistance, remains understudied. We combine computational modeling and electron microscopy of forebrain premotor axons controlling birdsong production.
View Article and Find Full Text PDFAcad Psychiatry
September 2025
University of Hawai'i, Honolulu, HI, USA.
Chem Sci
September 2025
Department of Chemistry, University of Hawai'i at Manoa Honolulu HI 96822 USA
By connecting laboratory dynamics with cosmic observables, this work highlights the critical role of reactions between highly reactive species in shaping the molecular inventory of the interstellar medium and opens new windows into the spectroscopically elusive corners of astrochemical complexity. The gas phase formation of distinct CH isomers is explored through the bimolecular reaction of tricarbon (C, XΣ ) with the vinyl radical (CH, XA') at a collision energy of 44 ± 1 kJ mol employing the crossed molecular beam technique augmented by electronic structure and Rice-Ramsperger-Kassel-Marcus (RRKM) calculations. This barrierless and exoergic reaction follows indirect dynamics and is initiated by the addition of tricarbon to the radical center of the vinyl radical forming a symmetric doublet collisional complex (CCCCHCH).
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