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Article Abstract
Tricin, a flavone present in rice bran, is confirmed as the major efficacious compound present in the enzyme-treated extract (ETZL), which protects against UVB-induced skin-aging. However, the suppressive mechanism of tricin on allergic responses remains unknown. The present study, therefore, aimed to determine the mechanisms of tricin and ETZL on mast cell degranulation in IgE-activated rat basophilic leukemia cell line (RBL-2H3) cells. We investigated the regulatory effects of tricin and ETZL on degranulation, production of cytokines and lipid mediators, and signaling proteins involved in the IgE-bound high-affinity IgE receptor activation, mitogen-activated protein kinase, arachidonic acid and Syk. The production of β-hexosaminidase, tumor necrosis factor-α, interleukin-4, leukotrienes (LT) B, LTC and prostaglandin E in IgE-stimulated RBL-2H3 cells were significantly inhibited by exposure to tricin or ETZL. Moreover, tricin and ETZL inhibit the phosphorylation of cytosolic phospholipase A2, 5-lipoxygenase and cyclooxygenase-2. Furthermore, the phosphorylation of Akt, ERK, p38, JNK, protein kinase Cδ and phospholipase Cγ1 were effectively suppressed by both samples. Exposure to tricin or ETZL also significantly decreases the phosphorylation of Lyn and Syk, but has minimal effect on Fyn. Taken together, our data indicate that tricin and ETZL are potential anti-allergic materials that could be applied for the prevention of allergy-related diseases.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249134 | PMC |
| http://dx.doi.org/10.3390/molecules25092084 | DOI Listing |
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Article Synopsis
- - Tricin, a compound found in rice bran, is effective in protecting against skin aging caused by UVB rays and may also help suppress allergic responses, although its mechanism is not fully understood.
- - This study focuses on tricin and an enzyme-treated extract (ETZL) to explore their effects on mast cell degranulation in a specific leukemia cell line, measuring influences on cytokines and various signaling pathways linked to allergic reactions.
- - Results show that both tricin and ETZL significantly reduce the release of allergy-related substances and inhibit several important proteins involved in inflammatory responses, suggesting they could be valuable for preventing allergy-related diseases.
Protection against UVB-induced damages in human dermal fibroblasts: efficacy of tricin isolated from enzyme-treated Zizania latifolia extract.
Biosci Biotechnol Biochem
March 2019
e Department of Food Science and Technology , Keimyung University, Daegu , Korea.
This study was undertaken to determine the effects of enzyme-treated Zizania latifolia (ETZL) and of its major compound tricin on skin photo-aging and to investigate the mechanisms involved. It was found ETZL and tricin suppressed matrix metalloproteinase (MMP) production and increased type I-procollagen production in UVB-irradiated human dermal fibroblasts (HDFs). Furthermore, ETZL and tricin significantly up-regulated the expressions of the antioxidant enzymes HO-1 and SOD1, reduced UVB-induced reactive oxygen species (ROS) generation and mitogen-activated protein kinase (MAPK) induction by ROS and thereby attenuated activator protein-1 (AP-1) expression.
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