98%
921
2 minutes
20
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.4155/tde-2020-0034 | DOI Listing |
Antioxid Redox Signal
September 2025
Department of Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Sepsis-induced cardiomyopathy (SIC) is a serious complication of sepsis. The relationship between SIC and protein acetylation, particularly the balance between acetylation and deacetylation in cardiomyocyte subcellular structures, as well as how nuclear-mitochondrial coordination maintains standard antioxidant stress capacity, remains unclear. This study focused on exploring the nuclear-mitochondrial regulatory mechanisms formed by the interplay of Sirtuin 3 (SIRT3) and Forkhead box O3a (FOXO3a).
View Article and Find Full Text PDFmBio
September 2025
Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, USA.
The human fungal pathogen changes its morphology in response to temperature. At 37°C, it grows as a budding yeast, whereas at room temperature (RT), it transitions to hyphal growth. Prior work has demonstrated that 15-20% of transcripts are temperature-regulated, and that transcription factors (TFs) Ryp1-4 are necessary to establish yeast growth.
View Article and Find Full Text PDFJ Appl Stat
February 2025
RBS, International University of Rabat, Technopolis, Sala-Al-Jadida, Morocco.
The paper first highlights important drawbacks and biases related to the common use of time-rescaling to assess the goodness-of-fit (Gof) of self-exciting temporal point process (SETPP) models. Then it presents a new predictive time-rescaling approach leading to an asymptotically unbiased Gof framework for general SETPPs in the case of single observed trajectories. The predictive approach focuses on forecasting accuracy and addresses the bias problem resulting from the plugged-in estimated parameters.
View Article and Find Full Text PDFArch Toxicol
September 2025
Norwegian Scientific Committee for Food and Environment, Norwegian Institute of Public Health, Oslo, Norway.
The transition from traditional animal-based approaches and assessments to New Approach Methodologies (NAMs) marks a scientific revolution in regulatory toxicology, with the potential of enhancing human and environmental protection. However, implementing the effective use of NAMs in regulatory toxicology has proven to be challenging, and so far, efforts to facilitate this change frequently focus on singular technical, psychological or economic inhibitors. This article takes a system-thinking approach to these challenges, a holistic framework for describing interactive relationships between the components of a system of interest.
View Article and Find Full Text PDFRNA Biol
September 2025
Department of Stem Cell Biology, School of Medicine, Konkuk University, Seoul, Republic of Korea.
Neural stem cells (NSCs) are multipotent stem cells with self-renewal capacity, able to differentiate into all neural lineages of the central nervous system, including neurons, oligodendrocytes, and astrocytes; thus, their proliferation and differentiation are essential for embryonic neurodevelopment and adult brain homoeostasis. Dysregulation in these processes is implicated in neurological disorders, highlighting the need to elucidate how NSCs proliferate and differentiate to clarify the mechanisms of neurogenesis and uncover potential therapeutic targets. MicroRNAs (miRNAs) are small, post-transcriptional regulators of gene expression involved in many aspects of nervous system development and function.
View Article and Find Full Text PDF