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The Seventh Annual Deep Brain Stimulation (DBS) Think Tank held on September 8th of 2019 addressed the most current: (1) use and utility of complex neurophysiological signals for development of adaptive neurostimulation to improve clinical outcomes; (2) Advancements in recent neuromodulation techniques to treat neuropsychiatric disorders; (3) New developments in optogenetics and DBS; (4) The use of augmented Virtual reality (VR) and neuromodulation; (5) commercially available technologies; and (6) ethical issues arising in and from research and use of DBS. These advances serve as both "markers of progress" and challenges and opportunities for ongoing address, engagement, and deliberation as we move to improve the functional capabilities and translational value of DBS. It is in this light that these proceedings are presented to inform the field and initiate ongoing discourse. As consistent with the intent, and spirit of this, and prior DBS Think Tanks, the overarching goal is to continue to develop multidisciplinary collaborations to rapidly advance the field and ultimately improve patient outcomes.
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http://dx.doi.org/10.3389/fnhum.2020.00054 | DOI Listing |
J Rheumatol
August 2025
A. Ma, MD, PhD, Department of Medicine, University of California, and San Francisco VA Medical Center, San Francisco, California, USA.
Polymorphisms in the locus encoding the A20 protein are strongly associated with psoriatic skin and joint disease. Reduced A20 expression, driven by both genetic and epigenetic factors, underscores its critical role as a negative regulator of psoriatic disease (PsD). Our recent study using a germline knockin mouse model harboring a mutation in A20's seventh zinc finger, which impairs A20 binding to linear (M1) ubiquitin, revealed a spontaneous phenotype resembling psoriatic arthritis.
View Article and Find Full Text PDFMedicine (Baltimore)
August 2025
Department of Pain Spinal Minimally Invasive Centre, Sanya Central Hospital (Hainan Third People's Hospital), Hainan Province, China.
Background: Cancer pain is a common symptom among cancer patients, and although opioid drugs are effective, they have side effects and abuse issues. In recent years, mobile apps have gradually been used as digital healthcare for cancer pain management. By visualizing and analyzing the literature on the control of cancer pain through mobile apps, we aim to understand the current research status and hot issues in this field and explore future directions for digital smart healthcare research.
View Article and Find Full Text PDFPeerJ
August 2025
Department of Radiological Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
Background: Ovarian cancer is a significant global health concern, ranking as the seventh most common cancer and the eighth leading cause of cancer-related deaths among women. Annually, it claims the lives of approximately 207,000 women worldwide. Early detection is crucial, as most cases are diagnosed at advanced stages, resulting in a 5-year survival rate of less than 20%.
View Article and Find Full Text PDFPLoS One
July 2025
Department of Critical Care Medicine, Seventh People's Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Aims: Depression, a leading contributor to the global disease burden, exhibits alarming increases in incidence and prevalence, with pronounced disparities across regions and genders. This study provides the first comprehensive analysis of depression burden from 1990 to 2021, integrating the latest Global Burden of Disease (GBD) 2021 data to identify critical hotspots and policy-relevant trends.
Methods: Estimated global, regional, and national burden of disease for depression from 1990-2021 by extracting incidence, prevalence, and DALYS from the Global Burden of Disease(GBD) database 2021.