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http://dx.doi.org/10.1183/13993003.00688-2020 | DOI Listing |
Pediatr Res
September 2025
Department of Pediatrics, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China.
Background: Glucagon-like peptide-1 (GLP-1) shows promise for treating hyperoxia-induced bronchopulmonary dysplasia (BPD), but its mechanisms remain unclear. This study investigated the effects and potential mechanisms of GLP-1 using a hyperoxia-induced neonatal BPD mouse model.
Methods: Sprague-Dawley (SD) newborn rats were randomly assigned to four groups: control, hyperoxia, hyperoxia+Liraglutide, and hyperoxia+Liraglutide+A779.
Viruses
August 2025
Department of Molecular and Cell Biology, Centro Nacional de Biotecnología-Consejo Superior de Investigaciones Científicas (CNB-CSIC), 28049 Madrid, Spain.
CD9 protein belongs to a family of proteins called tetraspanins, so named for their four-transmembrane-spanning architectures. These proteins are located in domains in the plasmatic membrane, called tetraspanin-enriched microdomains (TEMs). Several proteases and cellular receptors for virus entry cluster into TEMs, suggesting that TEMs are preferred virus entry portals.
View Article and Find Full Text PDFFront Med (Lausanne)
August 2025
Department of Biology, Faculty of Arts and Sciences, University of Balamand, El-Koura, Lebanon.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped positive sense RNA virus and the causative agent of COVID-19. The viral envelope includes the spike (S) glycoprotein which mediates the entry of the virus to the host cell. The S protein comprises the receptor binding domain (RBD) that is responsible for binding to the angiotensin-converting enzyme 2 (ACE 2) receptor on the surface of target cells.
View Article and Find Full Text PDFMol Ther Nucleic Acids
September 2025
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Cigarette smoking is associated with COVID-19 prevalence and severity, but the mechanistic basis for how smoking alters SARS-CoV-2 pathogenesis is unknown. A potential explanation is that smoking alters the expression of the SARS-CoV-2 cellular receptor and point of entry, angiotensin-converting enzyme 2 (ACE-2), and its cofactors including transmembrane protease serine 2 (TMPRSS2). We investigated the impact of cigarette smoking on the expression of ACE-2, TMPRSS2, and other known cofactors of SARS-CoV-2 infection and the resultant effects on infection severity .
View Article and Find Full Text PDFMicrob Pathog
September 2025
Department of Plasma Bio Display, Kwangwoon University, Seoul, 01897, Republic of Korea; Plasma Bioscience Research Center, Kwangwoon University, Seoul, 01897, Republic of Korea. Electronic address:
SARS-CoV-2 is a pressing global health issue, largely driven by uncontrolled viral replication and severe proinflammatory responses. Despite significant technological progress made by humanity, medical science has frequently found itself incapable of effectively addressing pathogenic outbreaks. Nonthermal plasma is a promising technology for combating pathogenic microorganisms.
View Article and Find Full Text PDF