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Stimuli-responsive bio-based polymeric systems are gaining considerable attention as intelligent versatile tools that show great potential in various fields. In this review, an overview is given of recent developments of stimuli-responsive bio-based polymeric systems. The characteristics of bio-based polymers in different applications are discussed and the superiority of these advanced stimuli-responsive bio-based polymeric systems is highlighted. Furthermore, several emerging applications of these systems including intelligent drug delivery, responsive food packaging and smart water treatment are discussed and the section of intelligent drug delivery is emphasized in detail. Finally, the respective prospects and limitations inherent to these systems are addressed.
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http://dx.doi.org/10.1039/c8tb02491j | DOI Listing |
Macromol Rapid Commun
August 2025
Department of Industrial and Mechanical Engineering, Rochester Institute of Technology, Dubai, United Arab Emirates.
4D printing of shape memory polymers (SMPs) offers transformative potential for patient-specific medical devices, yet current SMPs often face a trade-off between mechanical toughness and low-temperature activation. This study presents a novel PLA/APHA/TPU blend filament for 3D printing that overcomes this limitation by combining high strength and flexibility with low-temperature shape memory activation-features not previously achieved in PLA-based SMPs. The uniform dispersion of TPU and APHA in the PLA matrix creates a composite with enhanced tensile strength, modulus, and elongation, addressing the brittleness typical of neat PLA.
View Article and Find Full Text PDFAdv Healthc Mater
August 2025
School of Medicine and Health, Key Laboratory of Microsystems and Microstructures Manufacturing (Ministry of Education), Zhengzhou Research Institute, Harbin Institute of Technology, Harbin, China.
Diabetic oral wound healing is significantly impaired due to chronic inflammation, oxidative stress, and immune dysfunction, often resulting in delayed recovery or severe infections. Hydrogels have emerged as promising biomaterials for treating diabetic oral wounds due to their excellent biocompatibility, high drug-loading capacity, strong adhesion, and tunable degradation properties. This review examines recent advancements in hydrogel-based therapies for diabetic oral wound healing, with a particular focus on their applications in mucosal repair, periodontal tissue regeneration, and bone defect restoration.
View Article and Find Full Text PDFSoft Matter
June 2025
Univ. Grenoble Alpes, CNRS, Grenoble INP, LRP, 38000 Grenoble, France.
Bio-based surfactants, derived from microbial fermentation, are appealing biocompatible amphiphiles traditionally employed in depollution, pest control, personal care, cosmetics, and medicine, although their potential in biomedical scaffolds remains largely unexplored due to the limited adaptability of their rheological properties for extrusion-based 3D printing. This work demonstrates that microbial biosurfactants can function as low-molecular-weight gelators with facile, tunable rheological functionalities, enabling their integration into additive-free 3D printing processes. A hydrogel, formed by complexing a single-glucose oleyl lipid surfactant with calcium ions, exhibits shear-thinning behavior, viscoelasticity, yield stress, thixotropic response, and elongational properties, all essential for extrusion-based printing.
View Article and Find Full Text PDFCarbohydr Polym
May 2025
Key Laboratory of Bio-based Material Science and Technology of Ministry of Education, Northeast Forestry University, Harbin 150040, China. Electronic address:
Cellulose nanocrystal (CNC) -based circularly polarized luminescent (CPL) materials, which are responsive to external stimuli, have attracted increasing attention in developing smart chiral photonic materials. In this study, chiral nematic bio-composite CNC films with right-handed (R-) CPL emission and tunable dissymmetry factors (g) were prepared by encapsulating curcumin in chiral nematic CNC films via an evaporation-induced self-assembly strategy. The CPL active bio-composite CNC films exhibit multiple responsiveness to relative humidity (RH) and pH.
View Article and Find Full Text PDFGels
February 2025
Institute for Polymers, Composites and Biomaterials (IPCB)-National Research Council, 80055 Portici, Italy.
Bio-based polymeric stimuli-responsive materials have attracted increasing interest, especially in the pharmacological and nutraceutical fields. These materials mainly consist of macromolecules capable of conformational and chemical changes in response to external signals. One active molecule mostly used in bio-related areas is lactoferrin (Lf), which is attracting attention due to its beneficial effects (antimicrobial, anti-inflammatory, and anti-carcinogenic) on the human body.
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