98%
921
2 minutes
20
Falls affect a growing number of the population each year. Clinical methods to assess fall risk usually evaluate the performance of specific motions such as balancing or Sit-to-Stand. Unfortunately, these techniques have been shown to have poor predictive power, and are unable to identify the portions of motion that are most unstable. To this end, it may be useful to identify the set of body configurations that can accomplish a task under a specified control strategy. The resulting strategy-specific boundary between stable and unstable motion could be used to identify individuals at risk of falling. The recently proposed Stability Basin is defined as the set of configurations through time that do not lead to failure for an individual under their chosen control strategy. This paper presents a novel method to compute the Stability Basin and the first experimental validation of the Stability Basin with a perturbative Sit-to-Stand experiment involving forwards or backwards pulls from a motor-driven cable with 11 subjects. The individually-constructed Stability Basins are used to identify when a trial fails, i.e. when an individual must switch from their chosen control strategy (indicated by a step or sit) to recover from a perturbation. The constructed Stability Basins correctly predict the outcome of trials where failure was observed with over accuracy, and correctly predict the outcome of successful trials with over accuracy. The Stability Basin was compared to three other methods and was found to estimate the stable region with over more accuracy in all cases. This study demonstrates that Stability Basins offer a novel model-based approach for quantifying stability during motion, which could be used in physical therapy for individuals at risk of falling.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029948 | PMC |
http://dx.doi.org/10.1098/rsos.191410 | DOI Listing |
Mol Divers
September 2025
Department of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, 11942, Al Kharj, Saudi Arabia.
Cyclin-dependent kinase 20 (CDK20), also known as cell cycle-related kinase (CCRK), plays a pivotal role in hepatocellular carcinoma (HCC) progression by regulating β-catenin signaling and promoting uncontrolled proliferation. Despite its emerging significance, selective small-molecule inhibitors of CDK20 remain unexplored. In this study, a known CDK20 inhibitor, ISM042-2-048, was employed as a reference to retrieve structurally similar compounds from the PubChem database using an 85% similarity threshold.
View Article and Find Full Text PDFPhysiol Plant
September 2025
Centre of Molecular and Environmental Biology (CBMA), Department of Biology, School of Sciences of the University of Minho, Braga, Portugal.
The Mediterranean Basin, a hotspot for tomato production, is one of the most vulnerable areas to climate change, where rising temperatures and increasing soil and water salinization represent major threats to agricultural sustainability. Thus, to understand the molecular mechanisms behind plant responses to this stress combination, an RNA-Seq analysis was conducted on roots and shoots of tomato plants exposed to salt (100 mM NaCl) and/or heat (42°C, 4 h each day) stress for 21 days. The analysis identified over 8000 differentially expressed genes (DEGs) under combined stress conditions, with 1716 DEGs in roots and 2665 in shoots being exclusively modulated in response to this specific stress condition.
View Article and Find Full Text PDFBiology (Basel)
August 2025
College of Economics, Xinjiang University of Finance and Economics, Urumqi 830012, China.
Biodiversity in arid river basins is highly climate-sensitive, yet the multi-pathway relations among the environment, landscape structure, connectivity, and plant diversity remain unclear. Framed by a scale-place-space sustainability perspective, we evaluated, in the Hotan River Basin (NW China), how the environmental factors affect plant diversity directly and indirectly via the landscape configuration and functional connectivity. We integrated Landsat images (2000, 2012, and 2023), 57 vegetation plots, topographic and meteorological data; computed the landscape indices and Conefor connectivity metrics (PC, IIC); and fitted a partial least squares structural equation model (PLS-SEM).
View Article and Find Full Text PDFMath Biosci Eng
July 2025
Agricultural and Ecological Research Unit, Indian Statistical Institute, Kolkata 700108, India.
Ecosystem stability is increasingly threatened by rapid environmental fluctuations that alter species interactions and survival strategies. Traditional steady-state analyses often overlook transient dynamics that govern ecosystem responses to accelerating change. This study explored rate-induced tipping (R-tipping), a phenomenon where environmental change rates outpace species' adaptive capacity, triggering abrupt shifts between ecological states.
View Article and Find Full Text PDFBMC Genomics
September 2025
Jiangsu Key Laboratory for the Biodiversity Conservation and Sustainable Utilization in the Middle and Lower Reaches of Yangtze River Basin, College of Life Sciences, Nanjing Normal University, Nanjing, 210023, China.
Background: Understanding the genetic basis of long-distance migration in mammals provides important insights into the evolutionary mechanisms that enable species to adapt to changing environments. Despite its ecological significance, the molecular factors underlying this complex trait remain poorly understood.
Results: Our analyses reveal distinct evolutionary signatures associated with long-distance migration in mammals.