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More than two thirds of large rivers worldwide are fragmented, threatening freshwater biodiversity, river integrity, and the services that freshwater ecosystems provide for human populations around the globe. In an effort to alleviate the impacts of barriers, engineered solutions have been developed, though with somewhat underwhelming results. River restoration, especially dam removal, is viewed as the optimal option though seldom the go-to approach. In this study, we evaluated the effects of a large restoration project (pseudo dam removal) in River Kolding, Southern Jutland, Denmark, via a before-after-control-impact (BACI) approach. Using a large dataset of electrofishing data from 74 sites (including downstream unaffected sites, reconnected sites and upstream regulated sites), we found that habitat connectivity was restored successfully, with a large increase in young-of-the-year brown trout (Salmo trutta) at reconnected sites, reaching similar densities to downstream (non-affected) sites. We further observed a decrease in length at reconnected sites, suggesting that natural spawning and rearing habitats were successfully restored too.
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http://dx.doi.org/10.1016/j.jenvman.2020.110408 | DOI Listing |
J Cardiovasc Dev Dis
August 2025
Gottsegen National Cardiovascular Center, 1096 Budapest, Hungary.
Background: The influence of the initial ablation modality on pulmonary vein (PV) reconnection and substrate characteristics in redo procedures for recurrent atrial fibrillation (AF) remains unclear. We assessed how different thermal strategies-ablation index (AI)-guided radiofrequency (RF) versus cryoballoon (CB) ablation-affect remapping findings during redo pulmonary vein isolation (PVI).
Methods: We included patients undergoing redo ablation between 2015 and 2024 with high-density electroanatomic mapping.
Eur J Med Chem
November 2025
Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, 210093, China. Electronic address:
Breast cancer is a leading cause of death among women globally, with triple-negative breast cancer (TNBC) being the most aggressive subtype. To develop effective and safe chemotherapeutic drugs, we identified TOP2A as a potential target due to its differential expression between breast cancer and normal tissues. By targeting hydrogen bond-van der Waals sites, we discovered three active amino acid sites in TOP2A (E461, D463, and D543) and designed a β-carboline derivative, DM1, targeting DNA and TOP2A using a molecular generation model, local docking, and optimization.
View Article and Find Full Text PDFPLoS One
June 2025
Department of Neuroscience, Developmental and Regenerative Biology, The University of Texas at San Antonio, One UTSA Circle, San Antonio, Texas, United States of America.
The turnover and re-establishment of peripheral taste synapses is vital to maintain connectivity between primary taste receptor cells and the gustatory neurons which relay taste information from the tongue to the brain. Despite the importance of neuron-taste cell reconnection, the mechanisms governing synapse assembly in the taste bud are largely unknown. To determine whether nerve fiber connectivity is an initiating factor for the recruitment of presynaptic machinery in taste receptor cells, we use the expression of CALHM1 and Bassoon to identify presynaptic sites in type II (sweet, umami, bitter) and type III (sour) taste receptor cells, respectively.
View Article and Find Full Text PDFRestoring connectivity via assisted migration is a useful but currently underused approach for maintaining genetic diversity and preventing extirpations of threatened species. The use of assisted migration as a conservation strategy may be limited by the difficulty of balancing the benefits of reconnecting populations (including reduced inbreeding depression and increased adaptive capacity) with the perceived risk of outbreeding depression, which requires comprehensive knowledge of the landscape of adaptive, neutral, deleterious, and structural variation across a species' range. Using a combination of reduced-representation and whole-genome sequencing, we characterized genomic diversity and differentiation for the Arkansas Darter () across its range in the Midwestern US.
View Article and Find Full Text PDFHeart Rhythm
September 2025
From the Department of Cardiology, Saitama Medical University, International Medical Center, Saitama, Japan.
Background: CARTONET is a cloud-based system for the analysis of ablation procedures using the CARTO system. The current CARTONET R14 model employs deep learning, but its accuracy and positive predictive value (PPV) remain underevaluated.
Objective: This study aimed to compare the characteristics of the CARTONET system between the R12.