Article Synopsis
- Mitochondria are crucial for managing various cellular processes and responses during bacterial infections.
- Pathogens can alter mitochondrial functions and shapes to enhance their survival and avoid the host's immune system.
- The review discusses how bacteria and viruses affect mitochondria, impacting both the pathogens' behavior and the host's metabolic and immune responses.
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Article Abstract
Mitochondria have a central role in regulating a range of cellular activities and host responses upon bacterial infection. Multiple pathogens affect mitochondria dynamics and functions to influence their intracellular survival or evade host immunity. On the other side, major host responses elicited against infections are directly dependent on mitochondrial functions, thus placing mitochondria centrally in maintaining homeostasis upon infection. In this review, we summarize how different bacteria and viruses impact morphological and functional changes in host mitochondria and how this manipulation can influence microbial pathogenesis as well as the host cell metabolism and immune responses.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126537 | PMC |
| http://dx.doi.org/10.1016/j.tcb.2020.01.006 | DOI Listing |
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