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http://dx.doi.org/10.1016/j.jes.2020.01.015 | DOI Listing |
Biom J
October 2025
Department of Medical Biometry, Institute for Quality and Efficiency in Health Care (IQWiG), Cologne, Germany.
Hazards constitute key quantities for analyzing, interpreting, and understanding time-to-event data. Hazards and corresponding effect measures, such as the hazard ratio from the Cox proportional hazards model, have a valid causal interpretation if the hazard function is considered as a function in time rather than hazards at specific time points. In this comment, we would like to add two points: (1) The hazard ratio is also a useful population-level estimand with a valid causal interpretation.
View Article and Find Full Text PDFJ Allied Health
September 2025
Dep. of Medical Education, East Tennessee State University Quillen College of Medicine, PO Box 70582, Johnson City, TN 37614, USA.
Introduction: Educational approaches used in distance learning courses may be applicable to interprofessional education (IPE) simulation events to promote student engagement and learning.
Methods: Various strategies known to be effective when teaching online courses (real world applications, self-directed learning, reliance on previous life experiences, communities of practice, and emotional engagement) were incorporated into an interprofessional simulation event. Learning outcomes were captured quantitatively through student ratings of learning objective accomplishment and qualitatively through thematic analyses of learner reflections.
World J Clin Oncol
August 2025
Department of Surgery, Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital, Delhi 110001, India.
This letter comments on Wei 's study applying the Wave-Vision Transformer for oesophageal cancer classification. Highlighting its superior accuracy and efficiency, we discuss its potential clinical impact, limitations in dataset diversity, and the need for explainable artificial intelligence to enhance adoption in pathology and personalized treatment.
View Article and Find Full Text PDFNutrients
August 2025
Dipartimento di Scienze Cliniche e di Comunità (DISCCO), University of Milan, 20122 Milano, Italy.
Exercise for improving physical performance or for rehabilitation and exercise for recovering from altered to normal efficiency of muscles, should be matched by adequacy of nutrition, thus supporting increased metabolic needs. Exercise triggers production of energy, and this is followed also by increased production of oxidant molecules, therefore, epigenetic adaptation in cells requires complex modifications, driven by an optimal balance between syntheses and autophagy, maintaining integrity and promoting increased efficiency of cells. Mitochondrial biogenesis, energy production, anti-oxidants systems, protein syntheses, and removal of inefficient structures are all subordinate to the sufficient availability of essential amino acids and they are indispensable to promote, activate, and maintain protein syntheses of all the structures, either contractile proteins or organelles, and related enzymatic systems on which physical efficiency is based.
View Article and Find Full Text PDFDiagnostics (Basel)
August 2025
Intractable Disease Research Center, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
From the corona virus pandemic in Japan that started with the "Diamond Princess" accident, it became clear that rapid detection, a high sensitivity, multiple diagnostic items, one-step one-base point mutation detection, a fast speed of system development, portability (small size and light weight), full automation, random access, and other conditions are required for future point-of-care testing systems. The Eprimer-SmartAmp technology that was developed possesses characteristics fully aligned with these requirements. Building upon this platform, the "GenPad" system was subsequently established.
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