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Background: Various forms of hereditary polyposis have been described in the literature. Classical familial adenomatous polyposis (FAP) is a rare, autosomal dominantly inherited disease which is caused by a germline mutation in the adenomatous polyposis coli gene (APC). Patients with this diagnosis successively develop multiple polyps of the colon. Left untreated, FAP almost inevitably leads to malignant transformation.
Indication: We present the case of a 37-year-old patient with histologically confirmed, stenotic adenocarcinoma of the descending colon and an initially suspected hereditary polyposis due to multiple polyps in the descending and sigmoid colon.
Methods: The video describes the preoperative imaging as well as endoscopic findings and demonstrates the technique of a two-stage, robotically assisted proctocolectomy with ileal pouch-anal anastomosis (IPAA) and the creation of a temporary loop ileostomy.
Conclusions: With respect to the surgical treatment of classic FAP, restorative proctocolectomy (RPC) with ileal J-pouch construction can be regarded as an established standard procedure, despite controversy regarding various technical aspects. Minimally invasive strategies should be considered as an equivalent option compared to conventional techniques.
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http://dx.doi.org/10.1055/a-1084-4159 | DOI Listing |
Restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) is the standard surgical approach for patients with ulcerative colitis (UC) or familial adenomatous polyposis (FAP) seeking bowel continuity. While laparoscopy improves recovery, robotic-assisted surgery may offer advantages in pelvic procedures. However, its comparative efficacy remains unclear.
View Article and Find Full Text PDFInt J Surg Case Rep
September 2025
Department of Surgery, HRH Princess MahaChakri Sirindhorn Medical Center, Faculty of Medicine, Srinakharinwirot University, Nakhon Nayok, Thailand. Electronic address:
Background: Familial adenomatous polyposis (FAP) necessitates prophylactic colorectal surgery to prevent inevitable malignant transformation. While transanal approaches have gained acceptance in adult colorectal surgery, their application in pediatric populations remains limited. We present a young case and review current minimally invasive approaches for adolescent FAP management.
View Article and Find Full Text PDFBMJ Case Rep
June 2025
Surgery, UMass Chan Medical School, Worcester, Massachusetts, USA.
A man in his fourth decade of life was found to have an incidental, minimally symptomatic 18-mm distal pancreatic mass on imaging during workup of newly diagnosed familial adenomatous polyposis (FAP). EUS with fine needle aspiration demonstrated hepatocytic differentiation concerning for metastatic hepatocellular carcinoma, yet no liver lesions nor distant metastatic disease were noted on imaging. Tumour markers were not elevated, and next-generation sequencing demonstrated no somatic mutations.
View Article and Find Full Text PDFCureus
May 2025
General and Operative Surgery, Faculty of Medicine, Medical University of Varna, Varna, BGR.
Familial adenomatous polyposis (FAP) is a rare inherited disorder that is characterized by the formation of multiple adenomatous polyps in the colon that are precancerous. Diagnosis of the disease is of utmost importance in patients with a history of FAP, and prophylactic fibrocolonoscopies should be performed as early as the teenage years. This rare but significant genetic condition usually manifests in late adolescence or early adult years.
View Article and Find Full Text PDFCA Cancer J Clin
July 2025
Cancer Surveillance Research, American Cancer Society, Atlanta, Georgia, USA.
The number of people living with a history of cancer in the United States continues to rise because of the growth and aging of the population as well as improved survival through advances in early detection and treatment. To assist the public health community serve the needs of these survivors, the American Cancer Society and the National Cancer Institute collaborate triennially to estimate cancer prevalence in the United States using data from the Surveillance, Epidemiology, and End Results cancer registries, the Centers for Disease Control and Prevention's National Center for Health Statistics, and the United States Census Bureau. In addition, cancer treatment patterns are presented from the National Cancer Database along with a brief overview of treatment-related side effects.
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