Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
In recent decades, solid organ transplantation (SOT) has increased the survival and quality of life for patients with end-stage organ failure by providing a potentially long-term treatment option. Although the availability of organs for transplantation has increased throughout the years, the demand greatly outweighs the supply. One possible solution for this problem is to extend the potential donor pool by using extended criteria donors. However, organs from such donors are more prone to ischemia reperfusion injury (IRI) resulting in higher rates of delayed graft function, acute and chronic graft rejection and worse overall SOT outcomes. This can be overcome by further investigating donor preconditioning strategies, graft perfusion and storage and by finding novel therapeutic agents that could reduce IRI. relaxin (RLX) is a peptide hormone with antifibrotic, antioxidant, anti-inflammatory and cytoprotective properties. The main research until now focused on heart failure; however, several preclinical studies showed its potentials for reducing IRI in SOT. The aim of this comprehensive review is to overview currently available literature on the possible role of RLX in reducing IRI and its positive impact on SOT.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013572 | PMC |
| http://dx.doi.org/10.3390/ijms21020631 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Oral pharmacokinetics and tissue distribution of a homogeneous polysaccharide from Auricularia auricula-judae: dual-method validation of absorption and distribution.
Int J Biol Macromol
September 2025
Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, 24 Heping Road, Harbin, 150040, PR China. Electronic address:
Polysaccharides encounter significant challenges in vivo pharmacokinetic studies because of their complex structures and the limitations of current detection methods, thereby impeding their development and biomedical applications. This study systematically investigated the oral absorption characteristics and tissue distribution of ME-2, a homogeneous polysaccharide from Auricularia auricula-judae, using a dual-labeling pharmacokinetic approach. First, a fluorescein-5-thiosemicarbazide (FTSC)-based quantitative method was established to analyze plasma pharmacokinetics and tissue concentrations of ME-2, demonstrating robust methodological stability (intra-/inter-day RSD < 15 %) and accuracy (recovery rate 95-103 %).
View Article and Find Full Text PDFSafety and effectiveness of contraception among women with solid organ transplants: an updated systematic review.
Contraception
September 2025
Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Objective: To update a previous systematic review on contraceptive safety and effectiveness among women with solid organ transplants.
Study Design: We searched multiple databases from inception through December 7, 2022, for studies of any design that examined contraceptive safety and effectiveness for any contraceptive method among women with solid organ transplants. We extracted data from included articles; for studies that were not case series/reports, we assessed risk of bias and determined certainty of evidence.
Perchlorates as emerging contaminants: Sources, hazards, detection and remediation-An overview.
Chemosphere
September 2025
Department of Physical Chemistry and Technology of Polymers, Silesian University of Technology, 9 Strzody Street, 44-100 Gliwice, Poland. Electronic address:
Perchlorate contamination is a recent and significant issue in the context of environmental pollution. Perchlorates are mainly used as ingredients in solid propellants and pyrotechnic compositions. Perchlorate contamination of drinking water and food has recently become a human health concern, as studies have shown that they can interfere with the normal uptake of iodine by the thyroid gland, leading to a reduction in its production of triiodothyronine (T3) and thyroxine (T4) in vertebrates.
View Article and Find Full Text PDFBioinspired Vacuum Generation via Pressure-to-Vacuum Conversion for Manipulating all Phases of Matter.
Soft Robot
September 2025
Bioinspired Soft Robotics Laboratory, Istituto Italiano di Tecnologia, Genoa, Italy.
Animal diaphragm-lung systems are soft organs that generate a controllable vacuum. Elephants, as rare land animals, can manipulate all three states of matter using their lung-generated vacuum. In soft robotics, however, current vacuum generation relies on rigid components, and no single soft device effectively handles all states of matter.
View Article and Find Full Text PDFRecent Progress of 3D Printing Bioceramic Scaffolds for Bone Regeneration.
Tissue Eng Part B Rev
September 2025
The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China.
The reconstruction of critical-sized bone defects remains a challenging clinical problem. At present, the implantation of autogenous and allogeneic grafts is the main clinical treatment strategy but faces some drawbacks, such as inadequate source, donor site-related complications, and immune rejection, driving researchers to develop artificial bone substitutes based on distinct materials and fabrication technologies. Among the bone substitutes, bioceramic-based substitutes exhibit a remarkable biocompatibility, which can also be designed to degrade concomitantly with the formation of new bone.
View Article and Find Full Text PDF