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Article Abstract
Core-shell palladium cube@CeO (Pd cube@CeO) nanoparticles are shown to display oxidase-like activity. This is exploited in a method for determination of the activity of alkaline phosphatase (ALP). The Pd cube@CeO nanoparticles were thermally synthesized from Ce(NO), L-arginine and preformed Pd cube seeds in water. The Pd cube@CeO nanoparticles catalyze the oxidation of 3,3',5,5'-tetramethylbenzidine (TMB) by oxygen. This results in the formation of oxidized TMB (oxTMB) with an absorption peak at 652 nm. Ascorbic acid (AA) is generated from the hydrolysis of L-ascorbic acid 2-phosphate (AAP) catalyzed by ALP. It can reduce oxTMB to TMB, and this results in a decrease of the absorbance. The method allows for quantitative determination of the activity of ALP in the range from 0.1 to 4.0 U·L and with a detection limit down to 0.07 U·L. Endowed with high sensitivity and selectivity, the assay can quantify ALP activity in biological system with satisfactory results. Graphical abstractSchematic illustration of Pd cube@CeO core-shell nanoparticles for colorimetric determination of alkaline phosphatase.
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