Standardized Seed Extract of (HU-033) Attenuates Testosterone Propionate-Induced Benign Prostatic Hyperplasia α1-Adrenergic Receptors and Androgen/Estrogen Signaling.

Benign prostatic hyperplasia (BPH) is an age-related disease characterized by prostatic enlargement and is the most common urologic symptoms in elderly men 60 years of age and older. Previously, we documented that 70% ethanol (EtOH) seed extract of (QI) attenuates pathological condition of testosterone propionate (TP)-induced BPH rat model modulation of proliferation and apoptosis of prostate cells. Based on this potential of QI, we produced standardized seed extract of QI (HU-033) in order to prove further mechanisms. In this study, we aimed to suggest further mechanisms underlying the relationship between BPH and HU-033. Through not only cellular and nuclear receptor functional assays, but TP-mediated BPH rat model treated with HU-033, we demonstrated that HU-033 exerted antagonist effect on α1- and α1-adrenergic receptors and inhibitory effect on protein expression of androgen receptor and estrogen receptor alpha . Taken together, these results suggest that HU-033 is a novel candidate for the management of BPH.