Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Angiotensin II (AngII) is a peptide hormone that plays a key role in regulating blood pressure, and its interactions with the G protein-coupled receptors, AngII type-1 receptor (ATR) and AngII type-2 receptor (ATR), are central to its mechanism of action. We solved the crystal structure of human ATR bound to AngII and its specific antibody at 3.2-Å resolution. AngII (full agonist) and [Sar, Ile]-AngII (partial agonist) interact with ATR in a similar fashion, except at the bottom of the ATR ligand-binding pocket. In particular, the residues including Met128, which constitute the deep end of the cavity, play important roles in angiotensin receptor (ATR) activation upon AngII binding. These differences that occur upon endogenous ligand binding may contribute to a structural change in ATR, leading to normalization of the non-canonical coordination of helix 8. Our results will inform the design of more effective ligands for ATRs.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.str.2019.12.003 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Optimizing mucosal vaccination: Exploiting Lactobionic acid-modified chitosan for superior gene delivery systems.
Int J Biol Macromol
September 2025
CNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, 3004-504, Portugal; CIBB - Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, 3004-504, Portugal; Faculty of Pharmacy, University of Coimbra, Coimbra, 3000-548, Portugal. Electronic a
The increasing prevalence of respiratory disorders highlights the urgent need for effective mucosal vaccines that elicit targeted immune responses at pathogen entry sites. However, the advancement of mucosal vaccines is limited by challenges in antigen delivery and overcoming mucosal immune tolerance. In this study, we developed a gene delivery platform using chitosan functionalized with lactobionic acid (LA) to enhance targeting of antigen-presenting cells and to form stable DNA polyplexes with high transfection efficiency.
View Article and Find Full Text PDFSoy isoflavones mitigate atrazine-induced dopaminergic neuron damage via reshaping short-chain fatty acid-producing bacteria in gut microbiota and modulating the GPR43/GLP-1/GLP-1R axis.
Ecotoxicol Environ Saf
August 2025
Department of Hygienic Toxicology, School of Public Health, Harbin Medical University, 157 Baojian Road, Harbin, Heilongjiang Province 150081, China. Electronic address:
Atrazine (ATR), a widely used herbicide, is linked to dopaminergic neurotoxicity and persistent gut microbiota dysbiosis after early life exposure. However, whether the gut microbiota mediates ATR-induced loss of dopaminergic neurons remains unclear. Mice were exposed to ATR from juvenility (4 week) until adulthood (12 week), after which exposure ceased until the 20 week.
View Article and Find Full Text PDFInnovative approaches in alginate grafting: Amino acids of RGD peptide composition for biomimetic and biocompatible biomaterial.
Int J Biol Macromol
September 2025
Biofabrication Research Group, Renato Archer Information Technology Center (CTI), CP 13069-901 Campinas, SP, Brazil; Department of Chemistry, B(5)IDA Research Group, Simon Bolivar University, AP 89000, Caracas, Venezuela.
This study explores strategies to enhance the bioactivity of alginate by grafting individual amino acids-arginine, glycine, and aspartic acid-and their combinations onto the alginate backbone. Inspired by the cell-adhesive RGD sequence, this biomimetic approach aims to systematically investigate individual contributions of each residue-an aspect rarely studied in isolation-while also assessing synergistic effects. This methodology provides a more accessible, reproducible alternative to improve the functional performance of biopolymers, avoiding high cost and synthetic complexity typically associated with full peptide conjugation.
View Article and Find Full Text PDFRole of the TGF-β/SMAD pathway in tumor radioresistance to boron neutron capture therapy (BNCT) in a human cell line of colon adenocarcinoma.
Appl Radiat Isot
August 2025
Centro Oncológico de Medicina Nuclear. Instituto de Oncología "Ángel H. Roffo" (Universidad de Buenos Aires-Comisión Nacional de Energía Atómica), Av. San Martín 5481 (1417), CABA, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Godoy Cruz 2290, (C1425FQB),
BNCT is a radiotherapeutic modality of high LET energy for different solid tumors as colorectal carcinoma (CRC). Although clinical outcomes show advantages of BNCT, tumor recurrence remains a common challenge. Previously we have described the double strand DNA damage response (DDR) produced by BNCT.
View Article and Find Full Text PDFImpact of HRR Gene Subclass on Clinical Outcomes of PARP Inhibitors in Metastatic Castration-Resistant Prostate Cancer.
Clin Genitourin Cancer
August 2025
Department of Urology, Medical University of Sofia, University Hospital "Tsaritsa Yoanna", Sofia, Bulgaria.
Objective: This retrospective study evaluates the clinical significance of mutations in effector genes (BRCA1, BRCA2, PALB2, RAD51, FANCD2) versus sensor genes (ATM, ATR, CHEK1, CHEK2, NBS1) in patients with metastatic castration-resistant prostate cancer (mCRPC) classified as homologous recombination deficiency (HRD)-positive. The study assesses their predictive value for response to poly(ADP-ribose) polymerase inhibitors (PARPi) combined with androgen receptor signaling inhibitors (ARSi).
Design: A multicenter, retrospective real-world study conducted across 6 oncology hospitals in Bulgaria.